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JoVE Journal Medicine
Modified Technique for Coronary Artery Ligation in Mice
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Modified Technique for Coronary Artery Ligation in Mice

Article DOI: 10.3791/3093
March 29th, 2013 •
1, 1, 1
1Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg

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March 29th, 2013

The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.

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