End-diastolic Volume
End-diastolic Volume - Related Videos
11:04
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Cited by 8 •
2014
Accurate, causality-based quantification of global diastolic function has been achieved by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling (PDF) formalism. PDF generates unique stiffness, relaxation, and load parameters and elucidates 'new' physiology while providing sensitive and specific indexes of dysfunction.
06:04
Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
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Here we describe and compare two positions for obtaining the apical four-chamber view in mice. These positions enable the quantification of the right ventricular function, provide comparable results, and can be used interchangeably.
08:15
Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
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Cardiac pressure-volume loop analysis is the most comprehensive way to measure cardiac function in the intact heart. We describe a technique to perform and analyze cardiac pressure volume loops, using conductance catheters.
02:41
Constant Volume Calorimetry
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2020
Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
11:00
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Cited by 18 •
2017
Intracellular calcium recycling plays a critical role in regulation of systolic and diastolic function in cardiomyocytes. Here, we describe a protocol to evaluate sarcoplasmic reticulum Ca2+ reserve and diastolic calcium removal function in cardiomyocytes by a calcium imaging system.
FAQs
End-diastolic volume changes when the factors governing ventricular filling change. Blood volume and venous return determine how much blood reaches the heart, while ventricular compliance affects how the chamber accommodates that blood. Heart rate also contributes to the final value, and atrial contraction adds to filling during diastole. Together, these variables explain beat-to-beat variation.
An increase in EDV can increase stroke volume because greater filling stretches myocardial fibers before contraction. Through the Frank-Starling mechanism, that stretch can strengthen the subsequent ejection, but the relationship operates within physiological limits. Consequently, a larger EDV does not imply an unlimited rise in stroke volume; the response depends on the heart’s functional range.
Ventricular compliance influences EDV by affecting how filling translates into the amount of blood present before contraction. For a given filling process, a change in compliance can therefore change the resulting volume. This makes compliance an important interpretive variable when clinicians assess EDV, because the measurement reflects both incoming blood and the ventricle’s filling characteristics.
Heart rate matters because it changes the conditions under which diastolic filling occurs. Along with venous return, blood volume, compliance, and atrial contraction, heart rate helps determine the volume reached before systole. Thus, an EDV change should be considered in relation to the broader filling state rather than considered independently of other filling-related variables.
Echocardiography and cardiac magnetic resonance are the measurement methods identified for EDV. Their role is to provide a quantified view of ventricular filling that can support assessment of ventricular function. In clinical practice, these measurements help place cardiac filling and preload findings within the evaluation of disorders such as heart failure and valvular disease.
In heart failure, EDV provides information about ventricular filling and preload that can be considered alongside ventricular function. An increased or otherwise altered value may help characterize the cardiac state, but its meaning depends on the factors that determine filling, including venous return, blood volume, compliance, and heart rate. It can also support interpretation of treatment responses.
Valvular disease and treatment can alter the conditions affecting ventricular filling, making EDV useful for tracking how the heart’s filling state changes. Clinicians can compare measured values with the broader assessment of ventricular function to help interpret disease or response to therapy. The measurement therefore contributes to clinical evaluation without replacing consideration of the surrounding cardiac context.