Heart Function Assessment

Heart function assessment is the clinical evaluation of how effectively the heart generates pressure, moves blood, and maintains adequate circulation, making it central to diagnosing and monitoring cardiovascular disease. Clinicians combine symptoms and physical findings with electrocardiography, echocardiography, blood pressure measurements, and laboratory biomarkers to assess rhythm, chamber structure, valve activity, contractility, ventricular filling, ejection fraction, and cardiac output; exercise or advanced imaging may reveal abnormalities not present at rest. These complementary measurements help identify heart failure, ischemia, arrhythmias, and valvular disease, guide treatment decisions, and track response over time.

Heart Function Assessment - Related Videos

Research

JoVE Journal - Medicine
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Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy

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Cited by 36 •

2010

Langendorff-mode isolated heart perfusion, in conjunction with 31P NMR spectroscopy, combines the fields of biochemistry and physiology into one experiment. The protocol allows for the dynamic measurement of high energy phosphate content and turnover in the heart while concurrently monitoring physiologic function. When performed correctly, this is a valuable technique in the assessment of cardiac energetics.

Research

JoVE Journal - Medicine

Echocardiographic Assessment of the Right Heart in Mice

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Cited by 22 •

2013

This article provides a protocol for the echocardiographic assessment of right ventricular size and pulmonary hypertension in mice. Applications include phenotype determination and serial assessment in transgenic and toxin-induced mouse models of cardiomyopathy and pulmonary vascular disease.

Viral Gene Delivery in the Mouse Heart for Evaluating Gene Effects on Heart Function

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2026

Source: Lu, A., et al. Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk. J. Vis. Exp. (2022)The video demonstrates a method for ultrasound-guided intramyocardial injection of a recombinant viral vector in a mouse model. This technique enables targeted gene delivery to the heart for studying the effects of transgene expression on cardiac function.

Research

JoVE Journal - Medicine
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Myocardial Infarction and Functional Outcome Assessment in Pigs

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Cited by 52 •

2014

This protocol describes the porcine myocardial infarction (MI) model using a 90 min closed-chest coronary balloon occlusion of the left anterior descending artery (LAD), followed by reperfusion. Furthermore, the protocol for several outcome parameters, such as cardiac function, hemodynamics, microvascular resistance, and infarct size, are also presented.

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

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2023

The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart failure.

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