Hypertension
Hypertension - Related Videos
09:40
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Cited by 35 •
2016
Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.
06:34
Laser-Induced Chronic Ocular Hypertension Model on SD Rats
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Cited by 26 •
2007
Glaucoma is one of the major causes of blindness in the world. Elevated intraocular pressure is a major risk factor. Laser photocoagulation induced ocular hypertension is one of the well established animal models. This video demonstrates how to induce ocular hypertension by Argon laser photocoagulation in rat.
09:26
A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice
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Cited by 71 •
2016
Here, we present a protocol to induce ocular hypertension in the murine eye that results in the loss of retinal ganglion cells as observed in glaucoma. Magnetic microbeads are injected into the anterior chamber and attracted to the iridocorneal angle using a magnet to block the outflow of aqueous humour.
07:00
A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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Cited by 26 •
2013
Chronic ocular hypertension is induced using laser photocoagulation of the trabecular meshwork in mouse eyes. The intraocular pressure (IOP) is elevated for several months after laser treatment. The decrease of visual acuity and contrast sensitivity of experimental animals are monitored using the optomotor test.
01:28
Hypertension I: Introduction
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2025
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
FAQs
Increased vascular resistance makes it harder for blood to move through the arteries, while altered blood volume can increase the amount of fluid circulating through the vascular system. Either change can place sustained stress on arterial walls. Their interaction helps explain why clinical management may target vessel relaxation, fluid reduction, or both, depending on the factors identified.
The kidneys and neurohormonal systems help regulate fluid balance and vascular function. When their regulation becomes impaired, changes in blood volume or vessel behavior can persist rather than resolve. This mechanism is clinically important because treatment may modulate hormonal pathways or reduce fluid volume, addressing contributors to elevated pressure rather than focusing only on the measurement itself.
Sustained pressure places continuing mechanical stress on arterial walls and can contribute to injury in organs supplied by those vessels. The overview identifies heart disease, stroke, kidney damage, and other complications as important consequences. Evaluating associated organ injury therefore helps clinicians judge the condition’s impact and reinforces the need for long-term pressure control.
Lifestyle changes and antihypertensive medications address management through complementary routes. Lifestyle measures form part of the overall treatment strategy, while medications can reduce fluid volume, relax blood vessels, or modulate hormonal pathways. Combining these approaches is intended to lower pressure, reduce the likelihood of cardiovascular events, and help preserve organ function over time.
Clinical assessment begins with repeated blood pressure measurements rather than relying on a single reading. Healthcare professionals also review the medical history and evaluate associated risk factors or evidence of organ injury. Together, these steps provide a broader basis for understanding the patient’s condition and planning management aimed at reducing long-term complications.
Repeated measurements help establish whether elevated pressure is persistent, which is central to clinical assessment. They are interpreted alongside medical history, associated risk factors, and possible organ injury rather than in isolation. This combined evaluation supports decisions about whether lifestyle changes, antihypertensive medication, or both should be incorporated into a longer-term management plan.