Retrobulbar Hematoma

Retrobulbar hematoma is a collection of blood behind the eye that can rapidly threaten vision by increasing pressure within the orbit. It commonly develops after facial trauma, orbital or ocular surgery, or anticoagulant use; as blood accumulates, rising orbital pressure can compress the optic nerve and retinal circulation, restrict eye movement, and cause proptosis, pain, and visual loss. In clinical practice, recognizing these findings promptly is essential because treatment may require urgent orbital pressure relief, often through lateral canthotomy and cantholysis, to restore perfusion and reduce the risk of permanent optic nerve injury.

Retrobulbar Hematoma - Related Videos

Research

JoVE EoE - Neurotherapeutics

Minimally Invasive Endoscopic Procedure for Hematoma Removal from the Human Brain

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2025

Source: Pan, J. et. al., Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation. J. Vis. Exp. (2021)This video demonstrates minimally invasive endoscopic hematoma removal, using a navigation-guided sheath and endoscopic aspiration with saline irrigation to preserve brain structure.

Research

JoVE Journal - Genetics
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Systemic Treatment for Postnatal, Juvenile, and Runted Adult Mice by Retrobulbar Sinus Injection

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2024

This article provides a protocol and an accompanying video for the retrobulbar sinus injection of up to a total volume of 150 µL for postnatal, juvenile, and runted adult mice. This procedure is particularly well suited for the injection of small mice (15 g) when tail vein injection is not feasible.

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

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Cited by 12 •

2018

Here, we describe the induction of experimental nephrotic syndrome in 129S1/SvImJ mice by rapid retrobulbar injection of doxorubicin. We also treat nephrotic mice with sustained release pellets containing aprotinin to inhibit urinary serine protease activity and prevent sodium retention.

Education

JoVE Science Education - Clinical Skills

Lateral Canthotomy and Inferior Cantholysis

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2023

Source: James W Bonz, MD, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Lateral canthotomy is a potentially eyesight-saving procedure when performed emergently for an orbital compartment syndrome. An orbital compartment syndrome results from a buildup of pressure behind the eye; as pressure mounts, both the optic nerve and its vascular supply are compressed, rapidly leading to nerve damage and blindness if the pressure is not quickly relieved. The medial and lateral...

Induction of Graft Versus Host Disease in Mouse Models via Allogeneic Bone Marrow and Splenic Cell Transplantation

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2025

This video demonstrates the induction of intestinal graft-versus-host disease, GvHD, in a lethally-irradiated recipient mouse using allogeneic hematopoietic stem cells and GvHD-inducing splenic alloreactive T lymphocytes. This protocol helps establish a severe acute intestinal GvHD model to understand the mechanism of the disease and develop innovative therapeutic options.

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