Subcutaneous Syringe

A subcutaneous syringe is a sterile device used to deliver small volumes of medication into the fatty tissue beneath the skin, where it can be absorbed gradually into the circulation. During administration, a short, fine needle penetrates the skin while the syringe’s plunger pushes the medication into subcutaneous tissue, typically at an angle selected according to the needle length and the patient’s tissue depth. This route supports routine clinical therapies such as insulin and anticoagulant administration and can offer reliable self-injection outside healthcare settings. Correct syringe selection, injection technique, and site rotation help promote accurate dosing and reduce local tissue irritation.

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Research

JoVE EoE - Bacterial Growth and Techniques

Extraction of Apoplastic Bacteria Using a Syringe-Based Pressure Method

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2025

Source: Rufián, J. S., et al, Single-Cell Analysis of the Expression of Pseudomonas syringae Genes within the Plant Tissue. J. Vis. Exp. (2022)This video demonstrates a syringe-based pressure method for extracting apoplastic bacteria, which proliferate and form microcolonies within the apoplast, the intercellular space between plant cells. The method yields debris-free bacterial samples suitable for downstream single-cell analysis.

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

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Cited by 15 •

2013

Human tumor xenografts in immunodeficient mice are valuable tools to study cancer biology. Specific protocols to generate subcutaneous and intrahepatic xenografts from human hepatocellular carcinoma cells or tumor fragments are described. Liver regeneration induced by partial hepatectomy in recipient mice is presented as a strategy to facilitate intrahepatic engraftment.

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

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Cited by 23 •

2011

Murine skin and soft tissue infection model is utilized for assessing the virulence function of methicillin resistant Staphylococcus aureus (MRSA) and the host immunological responses. Here, we presented a subcutaneous infection model for skin and soft tissue infection.

Subcutaneous Injection of Bacterial Antigen to Induce Systemic Inflammation in a Murine Model

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2025

This video demonstrates the induction of systemic inflammation in an anesthetized mouse. The injection of mycobacterial antigen-adjuvant depots triggers cytokine release and localized inflammation. Lymphatic vessels open, enabling immune cell entry into lymph nodes and activation of T cells, which release pro-inflammatory cytokines, leading to widespread inflammation.

A Technique for Subcutaneous Abdominal Adipose Tissue Biopsy via a Non-diathermy Method

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Cited by 7 •

2017

We standardized an abdominal adipose tissue biopsy using a non-diathermy method performed under local anesthesia. Three cases of excessive post-operation bleeding out of 115 operations (2.61%) occurred.We conclude that an abdominal adipose tissue surgical biopsy using a non-diathermy method can be safely applied to healthy men.

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