Engineering Design Adjustments

Engineering design adjustments are deliberate modifications to a product, system, or process that improve performance, safety, reliability, cost, or usability. Engineers make these changes by evaluating requirements, analyzing test results, identifying design limitations, and revising materials, dimensions, components, or operating conditions while considering technical constraints and trade-offs. Through iterative design, modeling, prototyping, and validation, adjustments help align an engineered solution with its intended function and real-world environment. This process supports problem solving across fields such as mechanical, civil, electrical, and biomedical engineering, while reducing failure risks and improving efficiency before implementation or production.

Engineering Design Adjustments - Related Videos

Research

JoVE Journal - Biology
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Mouse Genome Engineering Using Designer Nucleases

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Cited by 14 •

2014

Designer nucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can be used to modify the genome of mouse preimplantation embryos by triggering both the nonhomologous end joining (NHEJ) and homologous recombination (HR) pathways. These advances enable the rapid generation of mice with precise genetic modifications.

Research

JoVE Journal - Developmental Biology

Magnetic Adjustment of Afterload in Engineered Heart Tissues

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2020

This protocol provides detailed methods describing the fabrication and implementation of a magnetics-based afterload tuning platform for engineered heart tissues.

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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Cited by 24 •

2013

We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

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Cited by 15 •

2014

Neural-machine interfaces (NMI) have been developed to identify the user's locomotion mode. These NMIs are potentially useful for neural control of powered artificial legs, but have not been fully demonstrated. This paper presented (1) our designed engineering platform for easy implementation and development of neural control for powered lower limb prostheses and (2) an experimental setup and protocol in a laboratory environment to evaluate neurally-controlled artificial legs on patients with...

Research

JoVE Journal - Neuroscience
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Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice

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Cited by 29 •

2014

Understanding the neural substrates of behavior requires brain circuit ensemble recording. Because of its genetic tractability, the mouse offers a model for circuit dissection and disease mimicry. Here, a method of designing and fabricating miniaturized probes is described that is suitable for targeting deep brain structure in the mouse.

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