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JoVE Journal
Biology

This content is Open Access.

Mouse Genome Engineering Using Designer Nucleases
 

Mouse Genome Engineering Using Designer Nucleases

Article doi: 10.3791/50930
April 2nd, 2014

Summary April 2nd, 2014

Designer nucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can be used to modify the genome of mouse preimplantation embryos by triggering both the nonhomologous end joining (NHEJ) and homologous recombination (HR) pathways. These advances enable the rapid generation of mice with precise genetic modifications.

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