Herringbone Pattern Microfluidics
Herringbone Pattern Microfluidics - Related Videos
07:53
Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
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Cited by 4 •
2016
We demonstrate the use of patterned aerosol adhesives to construct 3D paper microfluidic devices. This method of adhesive application forms semi-permanent bonds between layers, enabling single-use devices to be non-destructively disassembled after use and to ease folding complex nonplanar structures.
13:50
A Microfluidic Device with Groove Patterns for Studying Cellular Behavior
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Cited by 2 •
2007
We describe a protocol for the fabrication of microfluidic devices that can enable cell capture and culture. In this approach patterned microstructures such as grooves within microfluidic channels are used to create low shear stress regions within which cell can dock.
03:27
Microfluidic Patterning and Fluorescence-Based Tracking of Single-Cell Bacterial Growth
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2025
Source: Pioli, R., et al., Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly. J. Vis. Exp. (2021)This video demonstrates the method of capturing single fluorescently tagged Escherichia coli (E. coli) cells in microfluidic traps using a carbon-free suspension and controlled flow, followed by nutrient addition to trigger growth and fluorescence imaging of microcolonies.
12:19
Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe
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Cited by 2 •
2016
We present a protocol to perform subtractive patterning of live cell monolayers on a surface. This is achieved by local and selective lysis of adherent cells using a microfluidic probe (MFP). The cell lysate retrieved from local regions can be used for downstream analysis, enabling molecular profiling studies.
10:18
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
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Cited by 26 •
2017
Multilayer microfluidic devices often involve the fabrication of master molds with complex geometries for functionality. This article presents a complete protocol for multi-step photolithography with valves and variable height features tunable to any application. As a demonstration, we fabricate a microfluidic droplet generator capable of producing hydrogel beads.
FAQs
The repeating grooves interrupt the mainly parallel movement that normally characterizes small-scale laminar flow. Their angled geometry redirects portions of the fluid across the channel, creating transverse secondary currents. These currents move material between neighboring streamlines, so fluid elements encounter different regions of the channel instead of remaining in separate, parallel layers.
Chaotic advection repeatedly stretches and folds the fluid streams as they travel through the patterned channel. This action increases the contact area between different fluids and reagents, allowing their contents to interact more effectively at small scales. The result is improved mixing without relying on moving parts or external agitation.
In simple parallel laminar flow, neighboring fluid streams can remain largely separated because the motion follows orderly paths. A herringbone pattern disrupts that separation by generating transverse currents and repeatedly rearranging the streams. This distinction matters when a device must bring reagents into closer contact for reactions, preparation, or other fluid-handling tasks.
Fluids enter the microchannel and move along its length while the angled grooves redirect portions of the flow. The resulting secondary currents repeatedly stretch and fold the streams, increasing interaction between their contents during passage. Because the channel structures supply the mixing action, the process does not require moving components or external agitation.
Engineers can use this approach when rapid chemical reactions require efficient contact between reagents in a small device. The channel promotes repeated interaction as fluids move through it, supporting compact fluid handling for lab-on-a-chip systems. Its passive operation is relevant where mixing must occur without adding moving parts or external agitation.
Herringbone microchannels provide controlled fluid motion that can improve handling of samples, particles, and cells within compact microfluidic devices. Their mixing behavior supports sample preparation and particle or cell processing, while their small-scale format suits lab-on-a-chip systems. In engineering research, these capabilities connect channel design with practical fluid-handling workflows.