Clinimacs Prodigy
Clinimacs Prodigy - Related Videos
14:34
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
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2026
This bilingual protocol provides a computational drug discovery workflow assessing protein-ligand interactions of Polo-Like Kinases 1 to 3 (PLK1–3) and Absorption, Distribution, Metabolism, Excretion, Toxicity, and Stability (ADMET-S) properties of database-sourced natural molecules.
10:24
Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
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Cited by 23 •
2015
The goal of this protocol is to manufacture pathogen-specific clinical-grade T cells using a bench-top, automated, second generation cell enrichment device that incorporates a closed cytokine capture system and does not require dedicated staff or use of a GMP facility. The cytomegalovirus pp65-specific-T cells generated can be directly administered to patients.
FAQs
Magnetic cell selection is integrated with washing, activation, transduction, expansion, and harvest rather than performed as an isolated step. This coordination allows a programmed workflow to move selected immune cells through successive processing stages while limiting manual transfers. The integrated sequence supports more consistent preparation of cell products for functional experiments and development of adoptive cell therapy protocols.
The disposable tubing set provides the fluid-handling pathway through which cells undergo selection and subsequent processing. Because the workflow is organized around this closed set, operators can reduce manual handling during washing, activation, transduction, expansion, and formulation. This design contributes to standardized processing and can support biosafety as laboratory procedures advance toward clinical applications.
Programming specifies how the platform performs linked processing steps, helping apply the same sequence across preparations. Standardized execution can improve reproducibility when researchers isolate, modify, expand, and harvest immune cells under a defined protocol. Consistency is particularly valuable when comparing functional studies, optimizing cell therapy development, or translating an experimental workflow toward clinical use.
A workflow can combine isolation with controlled washing, activation, transduction, culture or expansion, and final harvest or formulation. These stages address different preparation needs, from enriching a leukocyte population to generating cells in a usable final form. Combining them within one programmed process helps connect upstream selection with downstream functional or therapeutic evaluation.
Researchers can use the platform when they need reproducible preparation of T cells, natural killer cells, or other leukocyte populations for functional studies. In infection-related work, these prepared cells can support investigations of host responses to infectious disease. The approach is also relevant when a laboratory is developing cell-based interventions or adapting research procedures for greater scale and consistency.
Translation benefits from a workflow that reduces manual handling while standardizing selection, culture, modification, and formulation steps. Clinimacs Prodigy can help laboratories evaluate whether an experimental process is reproducible and scalable before moving toward clinical application. Its closed processing arrangement and programmed operations also support attention to biosafety and consistency during protocol development.