Core-shell Structure
Core-shell Structure - Related Videos
02:10
The Nucleosome Core Particle
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2020
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins. The paradox Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
05:52
Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Cited by 21 •
2019
Presented here is a simple-to-use, core/shell, three-dimensional bioprinting set-up for one-step fabrication of hollow scaffolds, suitable for tissue engineering of vascular and other tubular structures.
07:59
Preparation of Nucleosome Core Particles Complexed with DNA Repair Factors for Cryo-Electron Microscopy Structural Determination
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2022
This protocol outlines in detail the preparation of nucleosomal complexes using two methods of sample preparation for freezing TEM grids.
09:51
A Polymer-based Piezoelectric Vibration Energy Harvester with a 3D Meshed-Core Structure
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Cited by 4 •
2019
In this study, we fabricated a flexible 3D mesh structure and applied it to the elastic layer of a bimorph cantilever-type vibration energy harvester for the purpose of lowering resonance frequency and increasing output power.
02:23
Visualizing the Effect of pH on Solubilization of the Influenza A Viral Core
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2026
Source: Stauffer, S. et al., In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation. J. Vis. Exp. (2016)This video demonstrates the effect of pH on the solubilization of influenza A viral cores. Gel electrophoresis and protein staining reveal the progressive disassembly of the core structure under acidic conditions.
FAQs
Shell thickness and permeability determine how readily surrounding conditions can reach the core and how quickly packaged material can leave it. A less permeable or thicker shell can provide stronger protection and slower diffusion, whereas altered shell properties can permit more accessible release. These design variables help tune delivery for antigens, adjuvants, antimicrobial agents, or imaging compounds.
Surface composition can change charge and molecular recognition, which in turn influences how a particle interacts with immune cells and pathogens. By engineering the outer layer rather than changing the packaged core, researchers can adjust biological interactions while retaining the core's cargo function. This separation of roles is useful when designing delivery or detection systems in infection research.
It is useful when one material must protect or carry a selected payload while another layer controls exposure at the interface. The core and shell can therefore provide different physical or chemical functions instead of forcing one composition to perform both tasks. This layered design supports tunable biomedical materials whose stability, release, surface behavior, or recognition can be adjusted independently.
A particle can place an antigen, adjuvant, antimicrobial agent, or imaging compound in the core while using the shell to alter surface charge or molecular recognition. The payload and interface consequently address different parts of the problem: the inner compartment supports packaging, and the outer layer influences interactions with immune cells or pathogens. This arrangement is relevant to vaccines and targeted therapy.
Development requires matching the core contents with the intended use, then selecting shell composition, thickness, and permeability to provide the needed protection, diffusion, or release behavior. Researchers can also engineer the surface for charge or molecular recognition. Together, these choices determine whether the material is better suited to vaccine delivery, antimicrobial treatment, pathogen detection, or imaging.
They may use them to package antigens or adjuvants for vaccine delivery, antimicrobial agents for targeted therapy, or imaging compounds for detection-related applications. The same architecture can also improve stability and provide tunable surface interactions. Its value is therefore not limited to one experimental goal: researchers can adapt the layers to delivery, pathogen detection, or development of biomedical materials.
Engineered surfaces can influence how particles interact with pathogens, while imaging compounds packaged in the core can support pathogen detection applications. Comparing designs with different shell compositions, thicknesses, permeability, or surface properties can help relate architecture to protection, release, or recognition behavior. In infection research, these observations guide development of more stable and tunable materials.