Fluorine Mri
Fluorine Mri - Related Videos
08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Cited by 8 •
2016
Tools to diagnose bile acid malabsorption and measure bile acid transport in vivo are limited. An innovative approach in live animals is described that utilizes combined proton (1H) plus fluorine (19F) magnetic resonance imaging; this novel methodology has translational potential to screen for bile acid malabsorption in clinical practice.
10:35
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Cited by 4 •
2015
The method presented here uses simultaneous positron emission tomography and magnetic resonance imaging. In the cerebral hypoxia-ischemia model, dynamic changes in diffusion and glucose metabolism occur during and after injury. The evolving and irreproducible damage in this model necessitates simultaneous acquisition if meaningful multi-modal imaging data are to be acquired.
06:06
Optogenetic Functional MRI
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Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
12:27
Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
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Cited by 9 •
2009
This work describes basic procedures of noninvasive small animal MRI and MRS in vivo.
08:36
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
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Cited by 4 •
2012
A technique is described for broadly opening the blood-brain barrier in the mouse using microbubbles and ultrasound. Using this technique, manganese can be administered to the mouse brain. Because manganese is an MRI contrast agent that accumulates in depolarized neurons, this approach enables imaging of neuronal activity.
FAQs
Biological tissues contain little naturally occurring fluorine, so administered fluorocarbon compounds can produce a low-background signal. This contrast helps distinguish the labeled material from surrounding tissue more specifically than signals arising from abundant endogenous molecules. In research, the reduced background supports clearer localization of fluorinated probes and improves interpretation of where labeled cells or compounds are present.
Fluorine signal intensity provides information about both the location and relative amount of fluorinated material. A detected signal can identify where a probe or labeled cell population has accumulated, while differences in intensity can indicate relative differences in the amount present. This makes the technique useful for following changes in labeled material over time or across disease sites.
Conventional proton MRI supplies anatomical imaging, whereas the fluorine channel adds highly specific molecular information from administered fluorinated probes. Using both signals can connect the position of labeled material with the surrounding tissue context. In immunology and infection research, this combination helps relate immune-cell distribution to inflammatory or infectious sites rather than viewing labeling information in isolation.
A study generally introduces a fluorocarbon compound or another fluorine-containing probe into the body, then detects its fluorine-19 signal with specialized imaging. Researchers interpret the signal according to its location and relative intensity, often alongside conventional proton MRI. When immune cells are labeled with fluorine-containing nanoparticles, the resulting images can show their distribution within the body.
Fluorine-containing nanoparticles can label immune cells before imaging, creating a detectable marker for those cells. Researchers can then examine whether labeled populations migrate toward, accumulate at, or persist within inflammatory or infectious sites. This provides a noninvasive way to study immune-cell movement and retention without relying solely on endpoint observations.
The method supports investigations of host responses, immune-cell therapies, and disease progression. By tracking labeled immune cells at inflammatory or infectious sites, researchers can evaluate where cells go, whether they accumulate, and how long they remain detectable. These observations help connect immune-cell behavior with changes occurring during infection or inflammation.