Human Blood Components

Human Blood Components are the distinct cellular and fluid constituents of blood, including plasma, red blood cells, white blood cells, and platelets, whose coordinated functions support transport, clotting, and immune defense. Plasma carries soluble proteins, including antibodies and complement, while leukocytes recognize pathogens through innate receptors or antigen-specific receptors and activate inflammatory and adaptive responses. Red blood cells deliver oxygen, and platelets form plugs at sites of vascular injury, linking blood composition to systemic homeostasis. In immunology and infection research, analyzing these components helps characterize host responses, identify disease-related changes, evaluate transfusion compatibility, and develop diagnostic and therapeutic strategies.

Human Blood Components - Related Videos

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Drug Binding to Blood Components

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2025

When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs). HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are further...

Research

JoVE Journal - Bioengineering

Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier

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Cited by 16 •

2013

Establishment of human models of the blood-brain barrier (BBB) can benefit research into brain conditions associated with BBB failure. We describe here an improved technique for preparation of a contact BBB model, which permits coculturing of human astrocytes and brain endothelial cells on the opposite sides of a porous membrane.

Research

JoVE Journal - Biology
Free Sample

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood

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Cited by 74 •

2015

This protocol allows for the reliable generation and characterization of blood outgrowth endothelial cells (BOECs) from a small volume of adult peripheral blood. BOECs can be used as a surrogate for endothelial cells from patients with vascular disorders and as a substrate for the generation of induced pluripotent stem cells.

A Comprehensive Approach to Analyze the Cell Components of Cerebral Blood Clots

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Cited by 1 •

2023

This study describes a fast and effective method for the cell component analysis of cerebral blood clots through clot dissolving, cell staining, and routine blood examination.

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

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Cited by 5 •

2016

The purpose of this manuscript is to present a method for measuring monocyte and granulocyte phagocytosis and oxidative burst activity in human blood samples.

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