Nalt Ablation
Nalt Ablation - Related Videos
12:21
Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue (NALT) in Mouse Responses to Vaccines
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Cited by 39 •
2012
Methods to examine contributions of the nasopharyngeal-associated lymphoreticular tissues (NALT) to nasal and systemic immune responses of mice to intranasal vaccines are described. We demonstrate a surgical procedure to establish a NALT-dependent mouse model and ex vivo cultures of extracted NALT.
11:21
Robotic Ablation of Atrial Fibrillation
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Cited by 12 •
2015
Pulmonary vein isolation (PVI) with an ablation catheter is a curative treatment for atrial fibrillation (AF). Robotic catheter systems aim to improve catheter steerability. Here, a procedure with a new robotic catheter system is presented. The goal of the procedure is electrical block between pulmonary vein and left atrium.
04:42
Targeted Neuronal Ablation Using Two-Photon Microscopy in a Zebrafish Larava
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2025
Source: Muto, A., et al. Ablation of a Neuronal Population Using a Two-photon Laser and Its Assessment Using Calcium Imaging and Behavioral Recording in Zebrafish Larvae. J. Vis. Exp. (2018) In this video, a two-photon laser ablation procedure is demonstrated, enabling the selective destruction of fluorescent neurons in agarose-immobilized zebrafish larvae. High-resolution imaging before and after the procedure confirms efficient neuronal damage, as observed by the absence of fluorescence.
07:16
Thermal Ablation for the Treatment of Abdominal Tumors
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Cited by 19 •
2011
A thermal tumor ablation procedure is described. The entire procedure is detailed, including pretreatment planning and imaging studies, anesthesia, adjuvant techniques to facilitate a percutaneous approach, imaging guidance of the ablation device to the tumor, thermal treatment, post-treatment care and follow-up.
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Cited by 11 •
2013
Catheter ablation is combined with placement of the WATCHMAN Left Atrial Appendage Closure Device to prevent ischemic stroke in a patient with non-valvular atrial fibrillation.
FAQs
NALT ablation removes or disrupts one candidate site for initiating mucosal immune responses. Researchers can then determine whether changes in nasal antigen sampling or local lymphocyte activation reflect a specific contribution from NALT, rather than a general loss of host defense. This approach also indicates whether systemic immune compartments can preserve protection when the nasal site is absent.
The model supports analysis of how inhaled antigens and pathogens are sampled in the nasal region, how local lymphocytes become activated, and how those events communicate with systemic immune compartments. These linked processes connect exposure at the upper airway with broader immunity, allowing investigators to ask whether NALT contributes to immune induction or whether other tissues can provide an alternative route.
An unchanged protective response after NALT disruption would not necessarily mean that NALT lacks a role. Other lymphoid tissues may compensate for its loss and maintain immune induction or host defense. Comparing functional outcomes in ablated and intact animals therefore helps separate an essential NALT contribution from a contribution that is redundant within the wider immune system.
The central comparison tests whether removing or functionally disrupting NALT changes immune responses or protection after relevant exposure. Differences support a role for NALT in the measured process, whereas similar outcomes suggest compensation by other lymphoid tissues or limited dependence on NALT. Interpretation should connect the observed result to nasal sampling, local activation, systemic communication, or protection.
In respiratory infection studies, investigators can use the model to test whether upper-airway immune induction contributes to protective host defense. Comparing animals with disrupted or intact NALT may show whether responses initiated near the nasal entry site influence infection-related outcomes. The experiment is especially informative when the infection begins with exposure to inhaled pathogens.
Mucosal vaccination studies can use NALT ablation to evaluate whether nasal lymphoid tissue contributes to the induction of protective immunity after an upper-airway antigen exposure. If vaccination outcomes change after disruption, NALT may participate in that response. If they remain similar, other lymphoid tissues may support immune induction, helping define how broadly nasal vaccination depends on NALT.
NALT ablation provides a way to examine whether immune events in the nasal region influence host responses relevant to pathogen transmission. Because the model targets a site involved in responses to inhaled pathogens, comparisons with intact animals can test whether NALT-dependent immunity affects protection or other transmission-related outcomes. This connects local upper-airway immunity with infection dynamics.