Pediatric Respiratory Diseases
Pediatric Respiratory Diseases - Related Videos
05:56
Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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2025
The goal of this protocol is to showcase the technique and use of point-of-care transient elastography for pediatric gastroenterologists monitoring hepatobiliary involvement and advanced cystic fibrosis liver disease in persons with cystic fibrosis.
01:29
Respiratory Syncytial Virus Disease
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2026
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
09:24
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
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Cited by 8 •
2017
This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry device.
10:15
Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Cited by 12 •
2017
Expansion of human pediatric esophageal epithelial cells utilizing conditional reprogramming provides investigators with a patient-specific population of cells that can be utilized for engineering esophageal constructs for autologous implantation to treat defects or injury and serve as a reservoir for therapeutic screening assays.
09:59
Respiratory Exam I: Inspection and Palpation
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2023
Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Disorders of the respiratory system with a chief complaint of shortness of breath are among the most common reasons for both outpatient and inpatient evaluation. The most obvious visible clue to a respiratory problem will be whether the patient is displaying any signs of respiratory distress, such as fast respiratory rate and/or cyanosis. In a clinical situation, this will always require...
FAQs
Children’s immune systems respond to respiratory pathogens while still developing, which can influence the course of illness. Immunology and infection research examines how these defenses recognize and respond to infectious agents, helping explain why respiratory conditions may present differently in infants, children, and adolescents and supporting more appropriate diagnostic and treatment decisions.
These causes disturb breathing through different biological pathways. Infectious agents involve pathogen-driven disease, whereas allergic or immune-mediated conditions reflect inflammation. Congenital abnormalities can affect respiratory structure or function, and environmental exposures may injure or irritate respiratory tissues. Distinguishing these categories helps connect the underlying cause with symptoms, diagnosis, and management.
Airway swelling and increased mucus can narrow the passages through which air moves, making normal breathing more difficult. In pediatric disease, these changes may occur alongside tissue injury or impaired gas exchange, so symptoms reflect both obstruction and reduced respiratory efficiency. Linking these mechanisms to clinical findings helps researchers interpret disease severity and progression.
Gas exchange allows the respiratory system to support the body’s breathing needs. When disease disrupts this function, the lungs may not effectively perform their normal respiratory role. Tissue injury, airway changes, or other disease-related disturbances can contribute to this problem, making gas exchange an important mechanism when evaluating illness and potential outcomes.
Evaluation should account for the possible source of respiratory dysfunction, including infection, allergic or immune-mediated inflammation, congenital abnormalities, and environmental exposure. It also considers how airway swelling, mucus, impaired gas exchange, or tissue injury contribute to symptoms. This integrated approach supports accurate diagnosis rather than treating all childhood respiratory illness as the same condition.
Studying immune responses to respiratory pathogens provides scientific context for prevention strategies. The resulting knowledge supports vaccination approaches intended to reduce infection risk and infection-control measures designed to limit pathogen transmission. Together, these measures address respiratory disease before or during exposure and are especially relevant to protecting children whose immune defenses are still developing.
Targeted therapies are relevant when treatment can be guided by the disease process contributing to respiratory dysfunction. Understanding whether infection, immune-mediated inflammation, structural abnormality, or environmental exposure is involved helps connect therapy with the underlying problem. This approach can support more focused care and contribute to improved long-term respiratory health in children.