Basilar Artery Cells
Basilar Artery Cells - Related Videos
07:19
Recording of Inward Rectifying K+ Currents in Freshly Isolated Basilar Artery Smooth Muscle Cells by Patch Clamp Technique
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2025
This protocol describes a rapid and efficient method for isolating smooth muscle cells from the rat basilar artery and recording inward rectifying potassium channel currents in these cells using the whole-cell patch clamp technique. It offers a novel approach for researchers studying the basilar artery and ion channels.
10:54
A Cell Culture Model of Resistance Arteries
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Cited by 5 •
2017
A cell culture model of resistance arteries is described, allowing for the dissection of signaling pathways in endothelium, smooth muscle, or between endothelium and smooth muscle (the myoendothelial junction). The selective application of agonists or protein isolation, electron microscopy, or immunofluorescence can be utilized using this cell culture model.
08:06
Isolation of Human Umbilical Arterial Smooth Muscle Cells (HUASMC)
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Cited by 8 •
2010
The umbilical cords are used to isolate smooth muscle cells by different ways. In this work we used the enzymatic treatment to isolated smooth muscle cells.
06:57
Arterial Line Placement
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2023
Source: Sharon Bord, MD, Department of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA When monitoring patients, it is important to obtain values that are accurate and reliable. Blood pressure monitoring is one of the essential vital signs, and for a majority of patients, measuring it utilizing non-invasive techniques provides accurate values. However, there are situations in which the blood pressure requires more exact, specific, and reliable measurements.
08:02
Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
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Cited by 16 •
2013
We have developed a novel and reproducible technique to isolate primary cultures of pulmonary artery smooth muscle cells (PASMC) from mice as young as P7, thereby allowing better study of the signaling pathways involved in neonatal smooth muscle cell contraction and relaxation.
FAQs
Endothelial cells sense changes in blood flow and release signaling molecules such as nitric oxide. These signals act on neighboring smooth muscle cells, influencing whether the vessel contracts or relaxes. This communication links mechanical conditions inside the artery with changes in vascular tone, helping explain how altered flow may affect blood delivery to the brainstem and posterior brain.
Smooth muscle cells regulate the vessel’s internal diameter by contracting or relaxing in response to endothelial signaling and other local conditions. Contraction can narrow the artery, whereas relaxation can widen it. Because diameter affects cerebral perfusion, changes in smooth muscle behavior provide an important cellular mechanism through which vascular tone and blood supply can be altered.
The basilar artery wall depends on coordinated activity among its cell populations rather than on one cell type alone. Endothelial signaling influences smooth muscle behavior, while connective-tissue cells contribute to wall structure and maintenance. Injury, inflammation, or abnormal remodeling can disrupt this coordination, potentially changing vascular tone, weakening the wall, or promoting disease-related structural changes.
Cell studies can clarify how normal vascular tone is controlled and how that control changes during disease. Researchers can examine cellular responses associated with injury, inflammation, and abnormal remodeling, then relate those changes to impaired cerebral perfusion or altered vessel-wall integrity. This information helps connect microscopic cellular behavior with broader mechanisms of cerebrovascular disease.
If signaling between endothelial and smooth muscle cells becomes abnormal, the basilar artery may not adjust its diameter appropriately. Excessive narrowing could reduce blood flow and contribute to ischemic injury, while disrupted regulation may also be relevant to vasospasm. Studying these cellular responses helps identify how vascular tone disturbances could affect perfusion in the posterior brain.
Abnormal remodeling of the artery wall can change its structural maintenance and may contribute to aneurysm-related disease. Examining the cells involved helps researchers investigate how wall changes develop and how inflammation or injury may influence them. The same cellular mechanisms provide a basis for exploring potential therapies aimed at preserving vascular function or limiting harmful cerebrovascular remodeling.