Bone Erosions
Bone Erosions - Related Videos
13:00
Modifying the Bank Erosion Hazard Index (BEHI) Protocol for Rapid Assessment of Streambank Erosion in Northeastern Ohio
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Cited by 5 •
2015
Streambank erosion potential can be evaluated and ranked using David Rosgen’s Bank Erosion Hazard Index (BEHI), however this protocol has significant limitations. Here we present protocol modifications to address time constraints, allow nonprofessionals to complete accurate assessments, and account for non-alluvial stream conditions in Northeast Ohio.
08:09
Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management
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Cited by 1 •
2017
Spatial patterns of soil erosion and deposition can be inferred from differences in ground elevation mapped at appropriate time increments. Such changes in elevation are related to changes in near-surface soil carbonates. Repeatable methods for field and laboratory measurements of these quantities and data analysis methods are described here.
08:49
Models of Bone Metastasis
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Cited by 115 •
2012
Animal models are frequently utilized to study cancer metastasis to bone. In this protocol we will describe two common methods of tumor inoculation for bone metastasis studies and briefly describe some of the analyses utilized to monitor and quantify these models.
06:45
Automated Joint Space Detection Improves Bone Segmentation Accuracy
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2025
The development of an automated joint space detection workflow enabled high-throughput segmentation of distinct murine hindpaw bones with >98% accuracy in wild-type animals. Flexible application to forepaws and paws with inflammatory-erosive arthritis was achieved, but with deprecated performance that warrants further optimization in future studies using publicly available data.
07:17
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Cited by 293 •
2016
Here we present a protocol for the dissection of hind limb long bones (femurs and tibiae) from the laboratory mouse. We further describe a rapid technique for bone marrow isolation from these bones that utilizes centrifugation for removal of bone marrow from the bone marrow space.
FAQs
Inflammatory immune signals can stimulate osteoclasts, the cells responsible for bone resorption, at the bone surface. When this activity exceeds local repair, cortical and subchondral bone may progressively deteriorate near the joint. This mechanism connects persistent inflammation with structural damage and explains why erosions can provide evidence of disease activity beyond pain or swelling alone.
The location of an erosion helps relate the structural change to the affected joint and the tissues immediately supporting it. In inflammatory arthritis, damage commonly develops near joint surfaces, including cortical and subchondral bone. Recording these locations helps clinicians evaluate disease patterns and distinguish inflammatory joint disorders from other potential causes of musculoskeletal symptoms.
Progression depends on whether bone removal continues to outpace repair. Inflammatory stimulation can maintain osteoclast activity, allowing small areas of damage to enlarge or accumulate over time. The resulting pattern is clinically meaningful because increasing erosive burden may signal continuing structural injury, whereas assessment over time can help determine whether disease control is limiting further damage.
Their number, distribution, and progression provide structural clues that complement the clinical assessment. A pattern of erosions near affected joints can support an inflammatory joint disorder, while the absence or different pattern of damage may prompt consideration of other explanations for pain. Interpretation should therefore integrate imaging findings with the broader disease presentation rather than rely on one lesion alone.
Clinicians may assess erosions with radiography, ultrasound, magnetic resonance imaging, or computed tomography. Using these imaging approaches supports examination of structural bone loss and allows the findings to be documented for comparison. The selected assessment can contribute to diagnosis and disease-severity evaluation, while repeat imaging may help determine whether erosive changes are progressing.
Assessment commonly considers the number, location, and progression of erosions. Counting lesions describes the extent of structural involvement, locating them shows how they relate to affected joints, and comparing examinations over time indicates progression. Together, these features provide a more informative picture of disease burden than a single isolated imaging finding.
Erosive findings can support diagnosis, indicate disease severity, and help clinicians evaluate response to therapy. Follow-up assessment focuses on whether structural damage is stable or continuing to progress. This information can contribute to treatment decisions and monitoring, particularly when clinicians need evidence about the course of an inflammatory joint disorder beyond current symptoms.
Extensive erosive damage may impair joint structure and function because progressive loss of cortical and subchondral bone compromises the supporting anatomy around an affected joint. The extent of damage therefore has practical relevance for assessing disease impact. In medicine, documenting erosive burden helps connect imaging abnormalities with the possibility of reduced structural integrity and impaired joint performance.