Cyanoacrylate Injection
Cyanoacrylate Injection - Related Videos
04:09
Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
0 Views •
2025
This protocol presents the management for gastroesophageal varices (GEVs) with endoscopic injection sclerotherapy assisted by cyanoacrylate and clips (CISC), which can improve the effectiveness of sclerotherapy and reduce complications.
09:01
A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating
0 Views •
2016
This article presents a protocol for the production of protein-based nanoparticles that changes the hydrophobic surface to hydrophilic. The produced nanoparticle is an assembly of gliadin-cyanoacrylate diblock copolymers. Spray coating with the produced nanoparticle changes the surface of target material to a hydrophilic surface.
05:58
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
0 Views •
Cited by 44 •
2013
Creating experimental retinal detachments with a reproducible and sustained height of detachment, and without subretinal hemorrhage, is important for studying the pathophysiology of photoreceptor cell loss in retinal disease and evaluating potential therapeutic interventions. Here, we report such a method in detail.
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
0 Views •
Cited by 1 •
2022
Here, we present a protocol to treat the great saphenous vein (GSV) and the small saphenous vein (SSV) affected by severe pathological reflux, using an original sclerosing and embolizing cyanoacrylate-based glue composed of N-butyl cyanoacrylate and methacryloxy sulfolane (NBCA+MS).
03:24
Intracerebroventricular Injection in Mouse: An Ommaya Mediated Direct Drug Administration Method to Deliver Drugs to Cerebral Ventricles of Mouse Brain
0 Views •
2023
This video demonstrates ommaya mediated intracerebroventricular injection in a mouse model. The method enables localized delivery of potential drug candidates and evades the blood-brain barrier.
FAQs
Contact with blood or other moist tissue initiates rapid polymerization, converting the liquid adhesive into a solid material. This change is central to treatment because the hardened cyanoacrylate can remain at the intended site and support either local hemostasis or vascular occlusion. The surrounding moisture therefore directly influences how the injected material produces its therapeutic effect.
Rapid polymerization allows cyanoacrylate to act promptly after delivery to a bleeding vessel or abnormal vascular channel. By quickly forming a solid barrier, it can produce local hemostasis and may help stabilize a patient during treatment. This speed is particularly relevant when clinicians need an immediate response rather than relying on a slower process to reduce blood loss.
Delivery precision determines whether the adhesive reaches only the intended vessel or spreads beyond the treatment site. Unintended embolization, meaning movement of material into other vessels, and tissue injury are important concerns when placement is not carefully controlled. Clinicians therefore select the delivery route and guidance method to limit unwanted distribution while achieving vascular blockage.
The technique is used especially for bleeding from gastrointestinal varices, where sealing the responsible vessels can provide hemostasis. In selected cases, clinicians also apply it to vascular malformations or other targeted vessels to create an occlusion. Its role is therefore broader than treatment of one bleeding source, but application depends on identifying a vessel or channel suitable for focused injection.
Treatment begins by identifying the bleeding vessel, varix, malformation, or other vascular target. Clinicians then introduce the adhesive through a needle or catheter, often using endoscopic or imaging guidance, and deliver it at the selected site. Contact with blood or moist tissue causes solidification, after which the team assesses whether the intended hemostasis or vascular occlusion has been achieved.
Imaging or endoscopic guidance is used when clinicians need to visualize the target vessel or vascular channel and control where the adhesive is delivered. These approaches can support accurate needle or catheter placement, especially when direct access to the target is difficult. Guidance is clinically important because inaccurate delivery may increase the risk of unintended embolization or tissue injury.
The immediate intended outcomes are control of bleeding or blockage of an abnormal vascular pathway. For gastrointestinal varices, successful local hemostasis can help stabilize the patient. For selected vascular malformations or targeted vessels, the goal is occlusion of the abnormal channel. Evaluation focuses on whether the adhesive acted at the intended site without causing unwanted embolization or tissue injury.