Glue-based Tma
Glue-based Tma - Related Videos
06:15
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Cited by 8 •
2015
This protocol aims to alleviate the limitation of poor cell engraftment for stem cell treatment of myocardial infarctions through the use of a hydrogel system and a fibrin-based glue. With this approach, cell-to-tissue contact post-infarction can be maintained, increasing the therapeutic potential of beneficial agents at the site of injury.
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Cited by 1 •
2022
Here, we present a protocol to treat the great saphenous vein (GSV) and the small saphenous vein (SSV) affected by severe pathological reflux, using an original sclerosing and embolizing cyanoacrylate-based glue composed of N-butyl cyanoacrylate and methacryloxy sulfolane (NBCA+MS).
08:40
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Cited by 12 •
2016
We describe the simplest protocol to prepare biodegradable medical glue that has an effective hemostatic ability. TAPE is a water-immiscible supramolecular aggregate prepared by mixing of tannic acid, a ubiquitous compound found in plants, and poly(ethylene) glycol, yielding a 2.5 times greater water-resistant adhesion compared with commercial fibrin glue.
10:10
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
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2019
This protocol describes light-triggered nuclear translocation of guests in living cells using caged molecular glue tags. This method is promising for site-selective nuclear-targeting drug delivery.
14:43
Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Cited by 12 •
2016
Electrospun nanofibers have a high surface area to weight ratio, excellent mechanical integrity, and support cell growth and proliferation. These nanofibers have a wide range of biomedical applications. Here we fabricate keratin/ PCL nanofibers, using the electrospinning technique, and characterize the fibers for possible applications in tissue engineering.
FAQs
The adhesive holds tissue cores or fragments in their assigned positions before processing, embedding, and sectioning. This stabilization helps preserve the planned arrangement as the specimens become part of a single support. Maintaining that spatial order allows each tissue sample to remain identifiable during later microscopic and molecular analyses.
Each specimen retains a defined location within the array, allowing observations from stained sections to be linked back to the corresponding tissue sample. This organization supports direct comparison among patient specimens under the same analysis. It is especially valuable when interpreting morphology, protein expression, or biomarker distribution across many samples.
Sections can be evaluated for tissue morphology as well as molecular patterns revealed by staining. The approach supports immunohistochemical assessment of protein expression and examination of biomarker distribution. Because multiple specimens are analyzed in parallel, investigators can assess these features across a defined collection of tissues using a consistent sectioning and staining framework.
By arranging many small specimens within one compact array, the method limits the amount of support material and tissue handling required for parallel analysis. It conserves limited tissue while allowing specimens to undergo comparable processing and staining. This shared workflow can improve consistency when large studies compare histopathological or biomarker findings.
Preparation begins by positioning tissue cores or fragments on a support and securing them with an adhesive. The assembled array is then processed, embedded, and sectioned. Sections can subsequently be stained for microscopic or molecular evaluation. Keeping the order established during assembly is essential for connecting each observation with its source specimen.
This technique is useful when investigators need to compare multiple patient specimens in histopathology, immunohistochemistry, or translational medicine. It is particularly relevant when tissue is limited and parallel assessment is desirable. A single organized array supports coordinated examination of morphology, protein expression, and biomarker distribution across the study set.