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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
JoVE Journal
Medicine
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JoVE Journal Medicine
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
DOI:

06:15 min

June 14, 2015

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Chapters

  • 00:05Title
  • 01:19Surgical Procedure
  • 03:25Patch Placement, Glue, and Suturing
  • 04:36Results: Fibrin Glue Does Not Harm Encapsulated Tissues
  • 05:46Conclusion

Summary

Automatic Translation

This protocol aims to alleviate the limitation of poor cell engraftment for stem cell treatment of myocardial infarctions through the use of a hydrogel system and a fibrin-based glue. With this approach, cell-to-tissue contact post-infarction can be maintained, increasing the therapeutic potential of beneficial agents at the site of injury.

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