High-throughput Sampler

A high-throughput sampler is a device or automated workflow that collects and processes large numbers of biological specimens or sample aliquots efficiently, making it valuable when medical studies require speed, consistency, and scale. It works by parallelizing sampling steps, using coordinated fluid handling and standardized collection conditions to reduce manual effort, variation, and processing time. In medicine, high-throughput samplers support clinical testing, biomarker discovery, pharmaceutical screening, and population-scale research by enabling rapid analysis of blood, tissue, or other patient-derived materials. Their use can improve experimental reproducibility and accelerate the translation of laboratory findings into diagnostic and therapeutic applications.

High-throughput Sampler - Related Videos

Research

JoVE Journal - Environment
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Deployment and Retrieval of Mineral Samplers

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2026

Many important reactive minerals are formed during in situ groundwater remediation; however, conventional drill core-based methods often present challenges in collecting these minerals. This article offers techniques for utilizing the Min-Trap, an innovative passive sampling device, to effectively collect and measure reactive minerals from conventional monitoring wells.

Research

JoVE Journal - Environment

Characterization and Application of Passive Samplers for Monitoring of Pesticides in Water

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Cited by 6 •

2016

A protocol about the characterization and application of five different passive sampling devices is presented.

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

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2015

Here we describe a cell-based reporter gene assay as a valuable tool to screen chemical libraries for compounds modulating post-transcriptional control mechanisms exerted through 3’ UTR.

A Protocol for Bioinspired Design: A Ground Sampler Based on Sea Urchin Jaws

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Cited by 17 •

2016

A protocol for bioinspired design is described for a sampling device based on the jaws of a sea urchin. The bioinspiration process includes observing the sea urchins, characterizing the mouthpiece, 3D printing of the teeth and their assembly, and bioexploring the tooth structure.

Research

JoVE Journal - Biochemistry
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High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography

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Cited by 16 •

2023

This protocol details high-throughput crystallization screening, ranging from the 1,536 microassay plate preparation to the end of a 6 week experimental time window. Details are included about the sample setup, the imaging obtained, and how users can perform analyses using an artificial intelligence-enabled graphical user interface to quickly and efficiently identify macromolecular crystallization conditions.

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