Ischemic Stroke

Ischemic stroke is a medical emergency in which a blood vessel supplying the brain becomes blocked, depriving downstream tissue of oxygen and nutrients. The obstruction usually results from a thrombus forming in a cerebral artery or an embolus traveling from another part of the circulatory system; reduced blood flow can cause rapid neuronal injury and infarction. Clinical assessment and brain imaging help distinguish ischemic stroke from other causes of neurological deficit and guide time-sensitive treatment, including clot-dissolving medication or mechanical thrombectomy in eligible patients. Research and clinical care also focus on preventing recurrence, limiting disability, and improving rehabilitation outcomes.

Ischemic Stroke - Related Videos

Research

JoVE EoE - Neurotherapeutics

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke

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2025

Begin with a rat subjected to middle cerebral artery occlusion, a surgical procedure that temporarily blocks blood flow to the brain tissue.This induces an ischemic stroke, leading to brain tissue damage.Next, remove the blockage to restore blood flow.Select rats that exhibit neurological deficits to ensure study relevance.Then, administer the test drug to the experimental group while injecting saline into the other group.Repeat the drug and saline administration.The test drug promotes...

Education

JoVE Core - Pathophysiology

Ischemic Stroke l: Introduction

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2026

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

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2026

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Inducing Ischemic Stroke via Middle Cerebral Artery Occlusion Using a Thread Bolt

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2025

This video demonstrates the process of inducing ischemic stroke in a rat model by occluding the middle cerebral artery (MCA) using a thread bolt. The procedure involves ligating the carotid arteries, inserting a thread bolt into the external carotid artery, and blocking blood flow from the MCA to the brain, leading to neuronal death and mimicking an ischemic stroke.

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

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Cited by 6 •

2014

Mouse models have become increasingly popular in studies of behavioral neuroscience. As models advance, it is important to develop sensitive behavioral measures specific to the mouse. This protocol describes the Pasta Matrix Reaching Task, which is a skilled motor task for use in mouse models of stroke.

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