Myosteatosis

Myosteatosis is the abnormal accumulation of fat within skeletal muscle, a change that can reduce muscle quality even when muscle size appears preserved. It develops when lipid droplets and adipose tissue infiltrate or surround muscle fibers, and clinicians commonly assess it using computed tomography, magnetic resonance imaging, or ultrasound based on muscle attenuation or tissue composition. In medicine, myosteatosis is studied as a marker of metabolic dysfunction, aging, frailty, and chronic disease, including cancer. Identifying it can improve risk assessment, support nutritional and exercise interventions, and help researchers evaluate how muscle composition influences treatment tolerance, recovery, and long-term outcomes.

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