Small Bowel Motility
Small Bowel Motility - Related Videos
36:30
Small Bowel Transplantation In Mice
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Cited by 2 •
2007
The mouse small bowel transplantation model has been recognized as an important tool to study mechanismes of immune rejection and screen new immunosuppressive drugs. However, this model is limited to use because the techniques involved is an extremely technically challenge. Now we introduce the modified technique.
09:16
Orthotopic Small Bowel Transplantation in Rats
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Cited by 4 •
2012
Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.
08:15
Gastrointestinal Motility Monitor (GIMM)
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Cited by 36 •
2010
Evaluation of colonic motility in the guinea pig distal colon with the Gastrointestinal Motility Monitor (GIMM) is a straightforward and simple to learn approach to quantitatively evaluate propulsive motility in the gastrointestinal tract.
08:52
An Introduction to Cell Motility and Migration
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2023
Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...
09:44
Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Cited by 32 •
2012
Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.
FAQs
The enteric nervous system coordinates local intestinal activity, while autonomic signals and gastrointestinal hormones modify the behavior of smooth muscle. These regulatory inputs work with electrical slow waves generated with help from interstitial cells of Cajal. Their interaction allows contractions to remain coordinated across mixing, digestion, nutrient absorption, and forward movement of contents.
Interstitial cells of Cajal help generate the electrical slow waves that organize smooth-muscle activity in the small intestine. Their influence operates within a broader control network that includes the enteric nervous system, autonomic signals, and gastrointestinal hormones. This coordination allows motility to support mixing and propulsion rather than producing unorganized muscle movement.
Segmentation and peristalsis serve complementary purposes rather than representing interchangeable contractions. Segmentation emphasizes repeated mixing of chyme within intestinal segments, whereas peristalsis creates forward propulsion. Together, they coordinate local processing with transit through the duodenum, jejunum, and ileum, supporting digestion and nutrient absorption while ultimately moving waste onward.
Feeding and fasting produce different motor patterns. After a meal, segmentation repeatedly mixes chyme, helping support digestive processing, while peristalsis moves contents forward. During fasting, the migrating motor complex clears residual material from the intestine. This distinction means that motility assessment may need to consider whether intestinal activity is occurring in a fed or fasting state.
Assessment becomes relevant when symptoms or clinical findings raise concern about abnormal intestinal movement, including obstruction, ileus, constipation, diarrhea, or other motility disorders. The purpose is not simply to document transit; it is to examine whether coordinated mixing and propulsion are functioning appropriately. Findings can support the medical evaluation of impaired intestinal movement and transit.
Manometry, imaging, and transit studies contribute different perspectives to a motility evaluation. Together, they can provide information about contraction patterns and the movement of intestinal contents. Using these approaches in medical assessment supports investigation of suspected obstruction, ileus, constipation, diarrhea, and motility disorders, linking test findings to clinically important abnormalities in transit.