Nerve-sparing Surgery
Nerve-sparing Surgery - Related Videos
07:44
The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
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Cited by 97 •
2011
The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.
04:34
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
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Cited by 5 •
2022
The modified surgery is a simplified method for mouse or rat spared nerve injury model that requires only one ligation and one cut to injure both common peroneal and sural nerves.
07:42
Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
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Cited by 7 •
2017
Traditional modeling of partial bladder outlet obstruction in rodents is fraught with animal mortality. A denervation injury from dissection around the proximal urethra and bladder neck is also of major concern. We developed and evaluated a safe and reliable mid-urethral obstruction model, avoiding the shortcomings of the traditional model.
15:04
An Anatomical Study of Nerves at Risk During Minimally Invasive Hallux Valgus Surgery
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Cited by 7 •
2018
Minimally invasive surgical (MIS) procedures rely on anatomical references to localize structures not directly visible to the surgeon. This manuscript describes a combined method of plane-by-plane dissection and sectional anatomy of fresh-frozen specimens to locate the structures at risk during MIS procedures.
01:30
Spare Receptors
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2023
Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
FAQs
These forces can injure nerve pathways that support sensation, movement, or organ function. Nerve-sparing planning therefore focuses on limiting unnecessary pulling, direct cutting, heat exposure, and pressure during tissue dissection. Controlling these mechanical and thermal stresses is important because the goal is not only to treat the diseased area, but also to reduce avoidable functional impairment.
Detailed anatomical knowledge helps surgeons anticipate where critical nerve pathways may lie in relation to diseased tissue. Magnification can make those structures easier to identify during careful dissection, supporting more precise tissue handling. Together, these resources help the surgical team distinguish treatment targets from nearby nerves and reduce the risk of damaging structures that contribute to important functions.
Intraoperative nerve monitoring can provide information about nerve pathways while the operation is in progress. Used alongside anatomical knowledge and direct visualization, it may help the surgical team identify or protect critical nerves as tissue is treated. This is particularly relevant when a lesion lies close to structures whose injury could affect sensation, movement, or organ function.
Preserving nerves does not replace treatment of the underlying disease. Surgeons must remove or treat the diseased tissue while limiting avoidable injury to nearby pathways. The balance is especially important when tumors or lesions are close to critical nerves. A successful approach therefore seeks both adequate disease management and preservation of functions that influence recovery and quality of life.
The relationship between the diseased tissue and nearby critical nerves is a central consideration. Nerve-sparing techniques become particularly important when tumors or other lesions lie close to pathways responsible for sensation, movement, or organ function. The relevant anatomy and the need for careful dissection, magnification, or monitoring can shape how the surgical team approaches the affected area.
This approach is relevant to operations involving the prostate, pelvis, head and neck, and limbs, where important nerves may be near the treatment area. By reducing avoidable nerve injury, it can support recovery, preserve quality of life, and improve functional outcomes. Its value is therefore measured not only by treatment of the condition, but also by retained bodily function.