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Medicine

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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
 

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

Article doi: 10.3791/3092
August 18th, 2011 Usage Statistics

Summary August 18th, 2011

The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.

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