Particle Deposition
Particle Deposition - Related Videos
02:33
Phase Transitions: Sublimation and Deposition
0 Views •
2020
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
12:33
Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
0 Views •
Cited by 25 •
2013
We describe experimental details of the synthesis of patterned and reconfigurable particles from two dimensional (2D) precursors. This methodology can be used to create particles in a variety of shapes including polyhedra and grasping devices at length scales ranging from the micro to centimeter scale.
09:27
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
0 Views •
Cited by 1 •
2012
We have used plasma enhanced chemical vapor deposition to deposit thin films ranging from a few nm to several 100 nm on nano-sized particles of various materials. We subsequently etch the core material to produce hollow nanoshells whose permeability is controlled by the thickness of the shell. We characterize the permeability of these coatings to small solutes and demonstrate that these barriers can provide sustained release of the core material over several days.
03:37
Subatomic Particles
0 Views •
2020
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...
02:41
Concentration and Purification of Viral Particles
0 Views •
2026
Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016).This video demonstrates the step-by-step process for concentrating and purifying lentiviral particles from a mixed suspension containing host cell debris. The procedure utilizes centrifugation, filtration, and PEG-salt precipitation to isolate viral particles while removing soluble impurities. The final product is resuspended in a...
FAQs
Particle size affects whether particles follow airflow, settle, or collide with airway surfaces. Larger particles are more likely to impact airway walls, particularly where the air path bends. Smaller particles can remain aligned with airflow or reach more distal regions through diffusion and sedimentation. This relationship helps predict regional accumulation after inhalation.
Changes in airflow direction can separate particle motion from the moving air stream. When particles cannot follow a bend as readily as the airflow, they may strike the airway wall through impaction. The effect is especially relevant for larger particles and helps explain why airway geometry must be considered when estimating regional deposition.
Particle shape and density influence how suspended material moves, while surface properties affect whether particles attach after reaching a biological boundary. These factors work alongside particle size and airflow rather than acting independently. Accounting for them can improve predictions of accumulation and help distinguish simple transport from persistent attachment in a respiratory setting.
Diffusion and sedimentation represent different ways smaller particles can reach respiratory regions. Diffusion reflects movement that allows particles to depart from the exact airflow path, whereas sedimentation reflects settling under the influence of gravity. Considering both mechanisms helps researchers interpret why particles may reach distal areas even when they do not directly impact airway walls.
Researchers evaluate the factors that control deposition, including particle size, shape, density, airflow, and surface properties, then use deposition models to predict where material accumulates. Those predicted locations support dose estimation by connecting transport behavior with regional exposure. This approach is useful when interpreting how much inhaled drug or contaminant may reach different parts of the respiratory system.
Deposition analysis helps determine whether inhaled drug particles are likely to accumulate in intended respiratory regions or elsewhere along the airway. The same reasoning informs respiratory-device design by identifying how particle and airflow characteristics affect delivery. Researchers can then relate predicted deposition patterns to treatment outcomes and refine approaches for delivering particulate materials through the lungs.