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DOI: 10.3791/4113-v
We have used plasma enhanced chemical vapor deposition to deposit thin films ranging from a few nm to several 100 nm on nano-sized particles of various materials. We subsequently etch the core material to produce hollow nanoshells whose permeability is controlled by the thickness of the shell. We characterize the permeability of these coatings to small solutes and demonstrate that these barriers can provide sustained release of the core material over several days.
The overall goal of this experiment is to coat nanoparticles, nano powders or drug particles with a plasma polymer in order to control the release of the core material. Begin with the preparation of silicon nanoparticles or calcium chloride nano powders for deposition breaking any agglomerations. Then place the particles in a plasma reactor and coat the nanoparticles by plasma polymerization of isopropanol using plasma enhanced chemical vapor deposition.
Next, to determine the permeability of the deposited, shell dissolve the core materials in a proper solvent while monitoring concentration results obtained show the permeability of the core material based on measurements of the ionic conductivity in a suspension of coated particles in water. The idea for this method came from the film deposition literature. A lot of work has been done on plasma deposition of thin films and flat substrates, but not on particles.
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