Particle Migration Speed

Particle migration speed is the rate at which particles move through a fluid, tissue, or other biological environment, making it an important measure in medicine and biomedical engineering. It depends on factors such as particle size and shape, fluid viscosity, applied forces, diffusion, and interactions with surrounding cells or tissues; under flow, drag and external forces determine transport behavior, while very small particles may also undergo Brownian motion. Measuring migration speed helps researchers evaluate drug-delivery systems, understand how diagnostic particles distribute in the body, and optimize targeted therapies, imaging agents, and particle-based medical devices.

Particle Migration Speed - Related Videos

Research

JoVE Journal - Engineering
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High-speed Particle Image Velocimetry Near Surfaces

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Cited by 19 •

2013

A procedure for studying transient flows near boundaries using high-resolution, high-speed particle image velocimetry (PIV) is described here. PIV is a non-intrusive measurement technique applicable to any optically accessible flow by optimizing several parameter constraints such as the image and recording properties, the laser sheet properties, and analysis algorithms.

Research

JoVE Journal - Bioengineering

Study of Cell Migration in Microfabricated Channels

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Cited by 43 •

2014

A quantitative method to study spontaneous migration of cells in a one-dimensional confined microenvironment is described. This method takes advantage of microfabricated channels and can be used to study migration of large number of cells under different conditions in single experiments.

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

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Cited by 26 •

2012

This method allows monitoring of cells in real time and quantitative measurements of different cell migration parameters such as speed, displacement, and velocity. Unlike the traditional methods, this real time approach is not based on endpoint quantitative migration measurements; instead it allows monitoring and calculating different parameters continuously.

Education

JoVE Science Education - Advanced Biology

The Transwell Migration Assay

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2023

Cells migration in response to chemical cues is crucial to development, immunity and disease states such as cancer. To quantify cell migration, a simple assay was developed in 1961 by Dr. Stephen Boyden, which is now known as the transwell migration assay or Boyden chamber assay. This set-up consists an insert which separates the wells of a multiwell plate into top and bottom compartments. Cells whose migration is to be studied are seeded into the top compartment and the chemoattractant...

An Introduction to Cell Motility and Migration

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2023

Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...

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