Popliteal Node

The popliteal node is a regional lymph node located within the popliteal fossa behind the knee, where it supports immune surveillance of the lower limb. It receives lymphatic drainage from portions of the foot, leg, and knee through superficial and deep lymphatic vessels, filters lymph, and exposes foreign material to lymphocytes and other immune cells. In medicine, examining the popliteal node can help identify infection, inflammation, or tumor spread in the lower extremity. Its anatomy also informs the assessment of lymphatic drainage patterns and the planning of clinical evaluations or procedures involving the leg and knee.

Popliteal Node - Related Videos

Research

JoVE Journal - Immunology and Infection
Free Sample

Intravital Imaging of the Mouse Popliteal Lymph Node

0 Views •

Cited by 27 •

2012

Recent advances in 2-photon microscopy have enabled real-time in situ imaging of live tissues in animal models, thereby enhancing our ability to investigate cellular behavior in both physiologic and pathologic conditions. Here, we outline the preparations required to perform intravital imaging of the mouse popliteal lymph node.

Research

JoVE EoE - Immune Systems and Components

A Dissection Method to Harvest Murine Popliteal Draining Lymph Nodes for Ex Vivo Imaging

0 Views •

2025

This video demonstrates a dissection technique to harvest popliteal draining lymph nodes from the mouse hind legs. Lymph nodes play a critical role in bridging innate and adaptive immunity, and harvesting intact lymph nodes — with a preserved tissue structure and cellular viability — can help study local and systemic immune responses.

Education

JoVE Science Education - Clinical Skills
Free Sample

Lymph Node Exam

0 Views •

2023

Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA The lymphatic system has two main functions: to return extracellular fluid back to the venous circulation and to expose antigenic substances to the immune system. As the collected fluid passes through lymphatic channels on its way back to the systemic circulation, it encounters multiple nodes consisting of highly concentrated clusters of...

A CFSE-Based Assay to Monitor Skin Dendritic Cell Migration to Draining Lymph Nodes in Infected Mice

0 Views •

2025

This video demonstrates an assay for monitoring dendritic cell migration following footpad infection with Mycobacterium bovis Bacille Calmette-Guérin BCG in mice. Upon bacterial infection, activated skin DC cells are labeled with a cell-permeable carboxyfluorescein diacetate succinimidyl ester (CFSE) dye. After a suitable interval for DC migration to the popliteal draining lymph node, the node cells are isolated and subjected to immunostaining for DC-specific surface markers. Identification of...

Sinoatrial Node Isolation from Mouse Model: A Procedure to Harvest SA Node from Murine Heart

0 Views •

2025

This video demonstrates the procedure to isolate sinoatrial node or SAN from mouse heart. The SAN houses the sinoatrial cells that initiates heartbeat by generating spontaneous action potentials.

View All Results

FAQs

Related Topics