Radiation Therapy Protocol
Radiation Therapy Protocol - Related Videos
08:17
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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Cited by 9 •
2015
Stereotactic ablative body radiation therapy (SBRT) involves the precise delivery of high-dose radiation to cancer tumor targets. A novel SBRT platform offers a first-of-its-kind gimbaled radiation accelerator mounted within a pivoting O-ring gantry capable of dynamic image-guided tumor tracking. Here, we describe dynamic tumor tracking for lung targets.
02:59
Biological Effects of Radiation
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2020
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
07:57
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
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Cited by 1 •
2022
Here we present a protocol to perform preclinical positron emission tomography-based radiotherapy in a rat glioblastoma model using algorithms developed in-house to optimize the accuracy and efficiency.
06:47
One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
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Cited by 17 •
2017
Research on ionizing radiation (IR)-induced clonogenic cell death is important for understanding the effects of IR on malignant tumors and normal tissues. Here, we describe a one-step assay for assessing the major modes of IR-induced clonogenic cell death based on morphology of 4',6-diamidino-2-phenylindole dihydrochloride (DAPI)-stained nuclei visualized by fluorescence microscopy.
13:07
A Protocol for Transcranial Photobiomodulation Therapy in Mice
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Cited by 24 •
2018
Photobiomodulation therapy is an innovative noninvasive modality for the treatment of a wide range of neurological and psychiatric disorders and can also improve healthy brain function. This protocol includes a step-by-step guide to performing brain photobiomodulation in mice by transcranial light delivery, which can be adapted for use in other laboratory rodents.
FAQs
Ionizing radiation deposits energy in targeted tissue and damages cellular DNA. When cancer cells cannot adequately repair that damage, they lose the ability to reproduce, which supports tumor control. The protocol therefore connects the intended treatment effect with a defined dose and delivery approach, while planning aims to limit unnecessary exposure to nearby healthy organs.
Fractionation divides the prescribed radiation into separate treatment sessions rather than delivering it all at once. This schedule gives healthy tissue time to recover between exposures while continuing to affect cancer cells. Timing and the number of fractions are therefore important protocol elements, because they help balance treatment effectiveness with protection of normal tissue.
Treatment goals determine how clinicians organize the radiation dose, timing, and delivery technique. A protocol may be designed around controlling the disease while preserving nearby organs, and its plan can be adjusted to support individualized care. Stating the goal first helps align technical decisions with the intended clinical outcome and later treatment evaluation.
Imaging supports radiation therapy planning by helping identify the tissue to target and the organs that should be protected. This information guides selection of the delivery approach and helps clinicians balance tumor treatment with normal-tissue preservation. Imaging is consequently a central part of planning, rather than an optional step after the protocol has been chosen.
Protocols may use external-beam radiation, brachytherapy, or combined treatment approaches. External-beam treatment delivers radiation from outside the body, whereas brachytherapy represents a distinct delivery strategy that can be incorporated into the plan. The selected approach depends on the structured treatment design, including its goals, dose, timing, and technique.
A complete protocol specifies the treatment goal, radiation dose, treatment timing, and delivery technique. It also relies on careful planning and imaging to guide targeting and organ protection. Together, these elements provide a consistent framework for delivering treatment and create a basis for evaluating whether the planned approach is supporting the desired clinical outcome.
A combined approach may be selected when the treatment plan calls for more than one radiation delivery technique. The protocol integrates the approaches with defined goals, dose, timing, and planning requirements. Because nearby organs must still be protected, imaging and careful coordination remain important when multiple techniques are included in a single treatment strategy.
Personalized care is supported by tailoring the protocol's treatment goals, dose, timing, and delivery technique to the planned clinical approach. Imaging helps refine targeting and organ protection, while treatment evaluation considers whether the plan is achieving its intended purpose. This structured process supports consistent care without treating every patient or disease situation identically.