Right Ventricular Failure

Right ventricular failure is a clinical syndrome in which the right ventricle cannot pump sufficient blood through the pulmonary circulation, making it an important cause of systemic venous congestion and reduced cardiac output. It develops when impaired contractility or excessive afterload overwhelms the ventricle, often disrupting right-sided filling and increasing venous pressures that produce peripheral edema, liver congestion, or jugular venous distension. In medicine, recognizing right ventricular failure supports evaluation with physical examination, echocardiography, and hemodynamic assessment, while treatment focuses on correcting the underlying cause, optimizing preload, and reducing harmful circulatory stress. Understanding its mechanisms improves risk assessment and guides care in cardiovascular and critical-care settings.

Right Ventricular Failure - Related Videos

Research

JoVE Journal - Biology

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

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Cited by 9 •

2019

Here, we provide a useful approach for studying the mechanism of right ventricular failure. A more convenient and efficient approach to pulmonary artery constriction is established using surgical instruments made inhouse. In addition, methods to evaluate the quality of this approach by echocardiography and catheterization are provided.

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

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Cited by 5 •

2023

Right ventricular failure and functional tricuspid regurgitation are associated with left-sided heart disease and pulmonary hypertension, which contribute significantly to morbidity and mortality in patients. Establishing a chronic ovine model to study right ventricular failure and functional tricuspid regurgitation will help in understanding their mechanisms, progression, and possible treatments.

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

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2026

This article presents a protocol to implant the left ventricular assist device (LVAD) into a piglet. This model represents a potent way to study the LVAD implantation in children and reveal the mechanism of ventricular reverse remodeling in LVAD treatment.

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure

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Cited by 23 •

2018

We present a surgical method to induce right ventricular hypertrophy and failure in rats.

A Murine Model of Pressure Overload-Induced Right Ventricular Hypertrophy and Failure by Pulmonary Trunk Banding

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2024

We describe a murine model of right ventricular pressure overload-induced by pulmonary trunk banding. Detailed protocols for intubation, surgery, and phenotyping by echocardiography are included in the paper. Custom-made instruments are used for intubation and surgery, allowing for fast and inexpensive reproduction of the model.

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