Adult Mouse Model
Adult Mouse Model - Related Videos
03:10
Establishing a Model of Zika Virus-Induced Neurodegeneration in an Adult Mouse
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2025
The video demonstrates intracerebral injection of Zika virus suspension in an adult mouse to induce neurodegeneration. An anesthetized mouse is secured in a stereotaxic frame, and a hole is drilled into the exposed skull for injection. A suspension of the Zika virus is injected into the brain tissue. The viral infection causes inflammation, leading to neurodegeneration.
08:27
Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
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Cited by 13 •
2015
We describe a method for creating a reliable model of cerebral venous hypertension in the adult mouse. This model has been widely described and tested in the rat. This new counterpart in the mice opens the possibility of using genetic modified animals and thereby broadens the applications of the model.
09:00
Olfactory Behavioral Testing in the Adult Mouse
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Cited by 68 •
2009
Fundamental, yet unique properties of the rodent olfactory system have led to its increasing study among biologists. A relatively simple assessment of its function is then also needed. Here we describe sensitive tests for the characterization of mouse olfactory sensitivity and preference.
06:42
Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis
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Cited by 29 •
2011
In this article, we present a simple, practical technique for cerebrovascular casting that is easy to perform and can be utilized to image the vascular tree of the adult mouse brain.
08:42
Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes
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Cited by 35 •
2016
This protocol describes a step-by-step method for the reproducible isolation and long-term culture of adult mouse cardiomyocytes with high yield, purity, and viability.
FAQs
Mature neural circuits allow researchers to examine processes that depend on established patterns of connectivity and organization. This makes the model useful for studying how interventions affect neural activity, behavior, or brain structure after development has progressed. Results can therefore reveal relationships that may not be apparent when investigating isolated cells or less developed biological systems.
Genetic, pharmacological, environmental, and surgical manipulations change biological conditions in distinct ways, allowing researchers to test competing explanations for neural or behavioral effects. Comparing outcomes across these conditions helps connect a manipulation with changes in neural activity, behavior, or brain structure. The approach supports mechanistic investigation rather than relying on a single type of experimental perturbation.
These interactions provide biological context that is not available from a single isolated component. Changes observed after a manipulation can be examined alongside effects across neural activity, behavior, and brain structure, helping researchers evaluate how processes operate within an intact organism. This context also supports comparison with cellular, computational, or human studies that examine complementary levels of biology.
A study typically begins by selecting a mature-mouse condition and applying a defined genetic, pharmacological, environmental, or surgical manipulation. Researchers then assess relevant outcomes, such as neural activity, behavior, or brain structure, and compare those measurements across experimental conditions. The resulting pattern helps evaluate whether the manipulation altered the process or dysfunction under investigation.
The model supports assessment across several outcome levels, including neural activity, behavior, and brain structure. Examining these measures together can show whether a manipulation produces coordinated changes or affects only one aspect of the system. Such comparisons help researchers interpret neurological function or dysfunction and develop hypotheses about relationships among observable behavioral, physiological, and structural effects.
It is especially useful when the research question concerns neurological function or dysfunction in the context of developed neural circuits and interacting biological systems. Researchers can use it to investigate mechanisms, evaluate experimental interventions, and compare outcomes across conditions. Findings can then guide hypothesis development and be considered alongside evidence from cellular, computational, or human approaches.