Click Tone Burst Stimulation

Click tone burst stimulation is an auditory neuroscience method that uses brief click sounds and frequency-defined tone bursts to activate the hearing pathway and measure its neural responses. A click delivers a short, broadband acoustic transient, whereas a tone burst contains a limited frequency range; both drive cochlear hair cells and produce time-locked activity that can be recorded as auditory evoked potentials. By comparing response timing, amplitude, and frequency specificity, researchers and clinicians can assess transmission through the auditory system, characterize hearing-related function, and investigate how neural circuits encode sound. The approach supports studies of sensory development, auditory disorders, and brainstem physiology.

Click Tone Burst Stimulation - Related Videos

Research

JoVE EoE - Neurotherapeutics

Continuous Theta Burst Stimulation to Reduce Responses to Ideological Threats

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2025

Source: Holbrook, C., et al. Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses. J. Vis. Exp. (2018)This video demonstrates the application of continuous theta burst stimulation (cTBS) to modulate responses to ideological threats. Electromyography (EMG) electrodes record motor signals, while a magnetic coil stimulates the primary motor cortex to determine the active motor threshold (aMT). The coil is then repositioned...

Theta-Burst Repetitive Transcranial Magnetic Stimulation to Promote Stroke Recovery in Rats

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2025

Take a rat with a focal ischemic stroke in the brain cortex, resulting in a compromised BBB, reduced blood flow, and excessive neuronal activity.Stroke also induces astrocyte activation, leading to the formation of neurotoxic astrocytes that release pro-inflammatory cytokines.This triggers neuroinflammation, leading to neuronal and endothelial cell degeneration.Restrain the rat and position the rTMS coil over the ischemic region.Administer theta-burst rTMS for several days.The electromagnetic...

Mapping the After-effects of Theta Burst Stimulation on the Human Auditory Cortex with Functional Imaging

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Cited by 13 •

2012

Auditory processing is the basis of speech and music-related processing. Transcranial Magnetic Stimulation (TMS) has been used successfully to study cognitive, sensory and motor systems but has rarely been applied to audition. Here we investigated TMS combined with functional Magnetic Resonance Imaging to understand the functional organization of auditory cortex.

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

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Cited by 7 •

2010

In this article, we examine the effects of Theta-Burst TMS stimulation on cortical plasticity in individuals suffering from Fragile X syndrome and individuals on the autistic spectrum.

Research

JoVE Journal - Medicine
Free Sample

Method to Measure Tone of Axial and Proximal Muscle

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Cited by 5 •

2011

We have developed a device (Twister) to study the regulation of tonic muscle activity during active postural maintenance. Twister measures torsional resistance and muscular responses in standing subjects during twisting of the body axis. The device can be flexibly configured to study various aspects of tonic control across the neck, trunk, and/or hips.

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