Endovascular Casting
Endovascular Casting - Related Videos
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 3 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
08:32
Indirect Fabrication of Lattice Metals with Thin Sections Using Centrifugal Casting
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Cited by 8 •
2016
An indirect additive manufacturing method combining a 3D printing of polymers with a centrifugal casting is outlined for manufacturing 3D octet truss metals (Al and Cu alloys) having a unit cell length of 5 mm with a wall thickness of 0.5 mm.
08:08
Simulator Training for Endovascular Neurosurgery
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Cited by 3 •
2020
Simulation of complex, high-risk procedures is critical to the education of medical trainees. A protocol for simulator-based endovascular neurosurgery training in a controlled academic environment is described. The protocol includes stepwise guidelines for trainees of varying levels, with a discussion of the advantages and limitations of this model.
06:42
Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis
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Cited by 29 •
2011
In this article, we present a simple, practical technique for cerebrovascular casting that is easy to perform and can be utilized to image the vascular tree of the adult mouse brain.
14:58
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Cited by 4 •
2017
Surgery is the gold standard for accessible arteriovenious malformations (AVMs), and pre-operative embolization can simplify this procedure. We describe our approach for staged endovascular embolization and open resection of AVMs, and provide a representative clinical example highlighting the advantages of a comprehensively trained neurovascular surgeon leading a multi-disciplinary clinical team.
FAQs
The material is perfused through the cerebral circulation so it occupies the vessel lumens, including branching pathways within the network. Once the resin or another casting medium cures, it retains the geometry of those spaces as a stable three-dimensional structure. This preserved form allows researchers to examine vessel arrangement after the surrounding biological tissue has been removed.
Tissue removal exposes the solidified vascular structure that would otherwise be concealed within the brain. Researchers can then inspect the cast directly or use microscopy and imaging to evaluate its branching pattern and microvascular architecture. The exposed replica also makes complex spatial relationships easier to analyze than when vessels remain embedded in surrounding tissue.
Endovascular casting can show how vessels branch, how small vessels are arranged, and where collateral pathways connect different parts of the circulation. Because the cast preserves spatial relationships across the network, investigators can assess the routes available for blood flow and identify structural changes associated with cerebrovascular injury or disease-related remodeling.
A typical workflow includes perfusing a curable resin or another casting material through the cerebral vessels, allowing the material to solidify within the lumens, and removing the surrounding tissue to expose the replica. The resulting cast is then examined through microscopy or imaging-based analysis, depending on whether researchers are studying fine architecture or broader network organization.
Researchers can apply endovascular casting when they need to characterize vascular structure in models of stroke, aneurysm, tumor vascularization, or neurodegenerative disease. The cast provides a structural record of vessel branching and remodeling, helping investigators examine how pathology changes cerebral networks and how collateral routes may contribute to altered blood-flow pathways.
The replica allows investigators to relate injury-associated changes to the three-dimensional organization of the vessel network. They can examine disrupted branching, altered microvascular architecture, or remodeled collateral pathways while retaining the spatial context of the circulation. These observations support structural analysis of how cerebrovascular damage may affect available routes for blood flow.