A New Murine Model of Endovascular Aortic Aneurysm Repair

Martin Rouer; Olivier Meilhac; Sandrine Delbosc; Liliane Louedec; Graciela Pavon-Djavid; Jane Cross; Josette Legagneux; Maxime Bouilliant-Linet; Jean-Baptiste Michel; Jean-Marc Alsac

doi:10.3791/50740

A New Murine Model of Endovascular Aortic Aneurysm Repair

JoVE Journal
Medicine
Author Produced

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Medicine

A New Murine Model of Endovascular Aortic Aneurysm Repair

Full Text

14,828 Views

08:51 min

July 7, 2013

DOI: 10.3791/50740-v

Martin Rouer¹, Olivier Meilhac¹, Sandrine Delbosc¹, Liliane Louedec¹, Graciela Pavon-Djavid^1,2, Jane Cross³, Josette Legagneux⁴, Maxime Bouilliant-Linet⁴, Jean-Baptiste Michel¹, Jean-Marc Alsac^1,5

¹INSERM U698 Cardiovascular Remodelling,Hôpital X. Bichat, AP-HP, Paris, ²Bio-Ingénierie des Polymères Cardiovasculaires (BPC),Institut Galilée - Université Paris 13, Paris, France, ³Service de Chirurgie Vasculaire, Hôpital Henri Mondor, AP-HP,Université Paris-Est Creteil, ⁴Ecole de chirurgie de l'assistance publique des hôpitaux de Paris, ⁵Service de Chirurgie Cardiaque et Vasculaire, Hôpital Européen Georges Pompidou, AP-HP,Université René Descartes

Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.

Hello, I'm Dr.We we are at the cardiovascular Research Department in Beha Hospital. The following sequences will show you the different steps to induce and then to treat an abdominal arctic aneurysm in rat rat abdominal aneurysm. Induction with elatta has been described by nature in 1990.

In this laboratory, the same year par published the first cases of endovascular abdominal aneurysm repair In humans, we present the first endovascular exclusion after triple A induced by elatta in rats with a coronary covered balloon expendable and graft, A short isof fluorine anesthesia, followed by a panus pen. Barbital intraperitoneal injection induces a long anesthesia time. Skin is shaved then disinfected after op pubic incision.

View the full transcript and gain access to thousands of scientific videos