Flair Imaging
Flair Imaging - Related Videos
01:23
Magnetic Resonance Imaging of Perivascular Spaces in the Human Brain During a Small Vessel Stroke
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2025
Perivascular spaces (PVS) are fluid-filled spaces around the brain blood vessels involved in fluid drainage.To examine alterations in PVS during a small vessel stroke, perform magnetic resonance imaging (MRI) of the basal ganglia region in the patient’s brain.The imaging protocol includes the T2-weighted fast spin echo and fluid-attenuated inversion recovery (FLAIR) sequences.T2-weighted imaging enhances the contrast between cerebrospinal fluid (CSF)-filled PVS and surrounding tissue.FLAIR...
01:22
Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging to Visualize Multiple Sclerosis Lesions
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2025
Position the head of a patient with multiple sclerosis inside the radiofrequency or RF coil of an MRI machine.Begin fluid-attenuated inversion recovery or FLAIR imaging. Select a brain slice containing lesions near CSF-rich areas.The system generates a strong magnetic field, aligning protons in healthy and lesioned brain tissue and CSF along its direction, creating net magnetization.Apply an inversion RF pulse to flip the magnetization of all protons, aligning them opposite to the magnetic...
13:45
Hybrid µCT-FMT imaging and image analysis
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Cited by 34 •
2015
We describe a protocol for hybrid imaging, combining fluorescence-mediated tomography (FMT) with micro computed tomography (µCT). After fusion and reconstruction, we perform interactive organ segmentation to extract quantitative measurements of the fluorescence distribution.
09:08
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Cited by 59 •
2011
Magnetic resonance imaging (MRI) has become an increasingly popular tool for examining the phenotype of genetically altered mice. This article illustrates the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI.
06:46
Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
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Cited by 4 •
2017
This paper explains the application of fluorescent imaging using an activatable optical imaging probe to visualize the in vivo activity of key matrix metalloproteinases in two different experimental models of inflammation.
FAQs
The inversion time determines when the longitudinal magnetization of cerebrospinal fluid crosses zero. Image acquisition is timed at that null point, so CSF contributes little or no signal, whereas many abnormalities retain detectable signal. This timing is the central contrast mechanism of FLAIR imaging and allows researchers to examine tissue bordering fluid-filled spaces with less CSF interference.
CSF can obscure nearby abnormalities on conventional T2-weighted images. Removing its signal increases the contrast between CSF and adjacent abnormal tissue. As a result, white-matter lesions, edema, demyelinating changes, and stroke-related abnormalities may become more conspicuous, supporting closer assessment of their location and extent within the brain.
Compared with conventional T2-weighted images, FLAIR imaging adds deliberate suppression of cerebrospinal fluid signal. This difference reduces the bright fluid background that can obscure abnormalities near fluid-filled spaces, while many lesions remain detectable. The resulting contrast can make structural pathology easier to recognize, particularly when white-matter or other periventricular changes are being assessed.
A FLAIR acquisition begins with an inversion-recovery pulse sequence, uses a carefully selected inversion time to null the longitudinal magnetization of CSF, and then acquires the image at that timing. The sequence therefore links preparation and readout: appropriate timing is necessary to obtain CSF suppression and the intended contrast between lesions and their background.
In neuroscience, FLAIR imaging supports assessment of white-matter lesions, brain edema, demyelination, stroke-related changes, and other brain pathology. Its value is especially apparent when abnormalities lie near CSF-containing spaces, where conventional T2-weighted contrast may make interpretation more difficult. The resulting images support evaluation of structural changes and their distribution.
FLAIR images help researchers and clinicians characterize structural changes by reducing CSF signal while preserving detectable signal from many lesions. This contrast can clarify abnormalities located near fluid-filled spaces and make their extent more apparent. Consequently, the technique contributes to interpreting edema, demyelination, white-matter pathology, and stroke-related changes in neuroscience research and clinical assessment.