Hemorrhage Induction
Hemorrhage Induction - Related Videos
04:43
Induction of a Subarachnoid Hemorrhage in a Mouse Model through Endovascular Perforation
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2025
The video demonstrates the induction of subarachnoid hemorrhage via endovascular perforation in a mouse model. An incision is made in the neck region of the anesthetized mouse to access the common carotid artery and its bifurcation. A filament is inserted through the arteries to perforate an intracranial artery branch, inducing subarachnoid hemorrhage.
16:31
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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Cited by 24 •
2011
The Hemorrhagic Shock model has been a reliable and reproducible resource facilitating the identification and understanding of signaling cascades associated with inflammation and end-organ damage after trauma. This article provides a step-by-step description of surgical and mechanical aspects associated with the Hemorrhagic Shock experimental procedure in mice.
10:44
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Cited by 60 •
2012
Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
02:29
Modeling Drug-Induced Hemorrhage in Zebrafish Larva
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2025
In this video, fertilized zebrafish embryos are dechorionated under a stereo microscope and then exposed to a cholesterol synthesis inhibitor, leading to the development of blood vessel ruptures and brain hemorrhages in the larvae. Hemorrhagic larvae, identifiable by distinct red spots, are subsequently separated under a microscope for further analysis.
11:33
Inductance
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2023
Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN This experiment will use inductive coils to demonstrate the concept of inductor and inductance. Magnetic induction will be demonstrated using a rod magnet inserted into or extracted away from the core of a coil to induce a transient electromotive force (emf) voltage in the coil, measured by a voltmeter. This experiment will also demonstrate the mutual inductance between...
FAQs
Collagenase degrades the vascular basement membranes that help support blood vessels, promoting local vessel rupture and blood accumulation. This creates a hematoma within brain tissue and allows investigators to examine consequences such as mass effect, edema, inflammation, and neuronal damage. The enzyme-based approach therefore models injury through vessel disruption rather than directly injecting blood alone.
The hematoma does more than mark the initial bleeding event. Its presence creates mass effect and edema, while the associated inflammatory response contributes to additional neuronal damage. Studying these linked processes helps researchers separate immediate consequences from secondary injury mechanisms, which is important when assessing whether a neuroprotective treatment, surgical strategy, or rehabilitation approach improves recovery.
Autologous blood injection introduces the subject's own blood into brain tissue, whereas collagenase causes local vessel rupture by degrading vascular basement membranes. These approaches reproduce hemorrhagic injury through different initiating events. Comparing them can help investigators determine whether observed findings relate primarily to blood accumulation, vessel disruption, or the broader tissue responses that follow the induced hemorrhage.
Injection site, blood or collagenase volume, and the timing of measurements are central variables in hemorrhage induction. Changing the site can alter the affected brain region, while volume influences the extent of the hematoma and associated tissue effects. Consistent timing is needed for meaningful comparisons of deficits, secondary injury, treatment responses, and recovery across experiments.
Behavioral testing can reveal motor and cognitive deficits after the induced injury, while tissue-level observations can address edema, inflammation, neuronal damage, and hematoma-related effects. These complementary outcomes connect functional impairment with underlying pathology. Together, they allow investigators to evaluate disease progression and determine whether an intervention changes injury severity or supports recovery.
A controlled injury model provides a consistent setting for testing neuroprotective treatments, surgical strategies, and rehabilitation approaches. Researchers can compare treated and untreated outcomes using motor or cognitive performance and measures of secondary injury. In neuroscience, this supports investigation of both the mechanisms that worsen hemorrhagic damage and interventions intended to improve functional recovery.