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Fixed Volume or Fixed Pressure

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Article DOI: 10.3791/2068-v 16:32 min June 6th, 2011
June 6th, 2011



The Hemorrhagic Shock model has been a reliable and reproducible resource facilitating the identification and understanding of signaling cascades associated with inflammation and end-organ damage after trauma. This article provides a step-by-step description of surgical and mechanical aspects associated with the Hemorrhagic Shock experimental procedure in mice.


Fixed Volume Fixed Pressure Murine Model Hemorrhagic Shock Blood Loss Traumatic Injury Signaling Events Sepsis Multiple Organ Dysfunction (MOD) Immune Function Pathophysiologic Conditions Systems Biology Cellular Communication Patterns Innate Immune Function Adaptive Immune Function Mouse Strains
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