Non-invasive Brain Imaging
Non-invasive Brain Imaging - Related Videos
04:57
Non-Invasive High-Frequency Ultrasound and Doppler Imaging of Rat Brain Hemodynamics
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2025
Source: Giustetto, P., et. al., Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging. J. Vis. Exp. (2015)In this video, we demonstrate the use of high-frequency ultrasound and photoacoustic imaging to study the vasculature and hemoglobin content in the rat brain. This method provides detailed insights into cerebral perfusion and blood oxygenation, enabling non-invasive analysis of brain vascular structures and oxygen distribution.
09:52
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Cited by 25 •
2013
Recently developed imaging techniques using near-infrared fluorescence (NIRF) may help elucidate the role the lymphatic system plays in cancer metastasis, immune response, wound repair, and other lymphatic-associated diseases.
01:37
Non-invasive Monitoring and Imaging in Animal Research
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Non-invasive technologies support the principles of 3Rs by enabling repeated data collection from the same animal without the need for euthanasia at multiple time points. These approaches reduce the number of animals required...
12:00
Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging
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Cited by 9 •
2015
The present work describes a new protocol to perform non-invasive high-frequency ultrasound and photoacoustic based imaging on rat brain, to efficiently visualize deep subcortical regions and their vascular patterns by directing signals on skull foramina naturally present on animal cranium.
05:15
Impedance-Based Measurements of Brain Cancer Cell Invasion
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2025
Source: Mudduluru, G., et. al. Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion. J. Vis. Exp. (2020)This video demonstrates an impedance-based assay to measure glioblastoma cell invasion and migration. Cells degrade the extracellular matrix, move through microporous membranes, and adhere to electrodes, generating impedance. This real-time analysis reflects their invasive potential for cancer research applications.
FAQs
Magnetic resonance imaging produces anatomical contrast by applying magnetic fields and radio waves. The resulting measurements support detailed visualization of brain structure, allowing investigators to examine anatomy relevant to neural organization. Structural information can then be interpreted alongside functional or process-related measurements when researchers need to connect physical brain features with broader neuroscience questions.
Functional MRI detects activity-related changes in blood oxygenation. Researchers use these changes as a measurement associated with brain activity, then relate the resulting patterns to behavior and neural circuits. This makes functional MRI valuable for studying functional organization while keeping its signal conceptually distinct from the detailed anatomical information provided by structural magnetic resonance imaging.
Positron emission tomography maps brain processes through radiolabeled tracers. Its tracer-based measurements complement the anatomical detail obtained with magnetic resonance imaging and the blood-oxygenation changes measured by functional MRI. Comparing these different forms of information can help researchers examine brain processes in relation to structure and activity rather than relying on a single measurement.
Complementary measurements allow researchers to examine different dimensions of the same neuroscience question. Structural imaging can show anatomy, functional MRI can identify activity-related blood-oxygenation changes, and positron emission tomography can map brain processes. Combining these perspectives helps link neural circuits to behavior, interpret findings more broadly, and track changes across investigations.
The choice depends on the information the study needs to obtain. Researchers may select magnetic resonance imaging for detailed anatomy, functional MRI for activity-related blood-oxygenation changes, or positron emission tomography for mapping brain processes with radiolabeled tracers. Matching the technique to the research question helps produce measurements relevant to structure, function, or process.
Non-invasive brain imaging supports diagnosis, treatment planning, cognitive studies, and research into neurological and psychiatric disorders. It also helps investigators develop targeted interventions by connecting observed brain organization or activity with behavior and disease-related questions. These applications make imaging relevant across both fundamental neuroscience research and clinical investigation.
Researchers can use non-invasive imaging to monitor changes over time, comparing measurements collected during different stages of a study or clinical process. Repeated structural, activity-related, or brain-process information can help reveal how neural patterns change and support evaluation of disorders, treatment planning, or the development of targeted interventions.