Quartz Needles
Quartz Needles - Related Videos
02:58
Rodent Brain Microinjection Using a Quartz Microneedle
0 Views •
2025
Source: Paolone, G., et al. Personalized Needles for Microinjections in the Rodent Brain. J. Vis. Exp. (2018).This video demonstrates a rodent brain microneedle injection using a quartz microneedle with holes. The microneedle is attached to a syringe and micropump to control the delivery rate. The needle with the injection solution is inserted into the brain with the delivery speed set at low. Once positioned, the delivery speed is increased. The needle is withdrawn after a brief pause.
10:06
Personalized Needles for Microinjections in the Rodent Brain
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Cited by 3 •
2018
We describe here a protocol for microinjection in the rodent brain that uses quartz needles. These needles do not produce detectable tissue damage and ensure reliable delivery even in deep regions. Moreover, they can be adapted to research needs by personalized designs and can be re-used.
07:37
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
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Cited by 7 •
2015
A protocol is presented for the preparation of piezoelectric macroporous epitaxial films of quartz on silicon by solution chemistry using dip-coating and thermal treatments in air.
09:51
Intraosseous Needle Placement
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2023
Source: Julianna Jung, MD, FACEP, Associate Professor of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA For unstable patients requiring urgent administration of medications, fluids, or blood products, establishing vascular access quickly is essential. However, there are many factors that can complicate placement of a peripheral intravenous cannula (PIV), and it is extremely common for PIV attempts to fail. PIV placement may be technically challenging in small...
08:25
Needle Thoracostomy
0 Views •
2015
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A tension pneumothorax is a life-threatening situation in which excess air is introduced into the pleural space surrounding the lung, either through trauma to the chest cavity or as a spontaneous leak of air from the lung itself. Air trapped within the pleural space causes separation of the lung from the chest wall, disrupting normal breathing mechanisms. Pneumothorax may be small without...
FAQs
Fused quartz provides a rigid shaft that can be pulled or sharpened into a narrow tip. This geometry helps the probe reach an individual cell or a precisely selected tissue location while limiting disruption during penetration. The resulting form supports experiments that require fine spatial access rather than broad tissue contact.
A hollow interior creates a path for controlled intracellular fluid exchange or microinjection after the tip enters a cell. This configuration allows investigators to introduce material or alter the cell’s internal environment while maintaining access through the same fine probe. It therefore extends the needle’s role beyond physical access to targeted cellular manipulation.
When connected to recording equipment, a quartz needle can provide access to electrical activity at the level of an individual cell or selected neural location. Its narrow tip supports high-resolution measurements with limited disruption, helping experiments examine cellular signaling rather than only activity averaged across larger regions of nervous tissue.
A pulled or sharpened shaft produces the narrow end needed for precise penetration of cell membranes or nervous tissue. The tip’s small, rigid form supports access to selected targets and is associated with limited disruption. Consequently, tip formation is central to balancing reliable entry with the spatial precision required for cellular neuroscience.
The experimental workflow begins by selecting a needle configuration suited to the intended task, such as recording, intracellular exchange, microinjection, labeling, or manipulation. The probe is then connected to the appropriate recording or delivery setup and directed toward the selected cell or tissue location. The configuration determines what information or intervention the experiment can provide.
A hollow micropipette is appropriate when the experiment requires intracellular fluid exchange or microinjection. A configuration connected to recording equipment is instead suited to measuring electrical activity. This distinction lets investigators match the probe’s internal structure and external connections to the experimental objective, whether they need cellular access for delivery or measurement.
Quartz needles support intracellular electrophysiology, neuronal labeling, microinjection, and studies of cellular mechanisms underlying neural signaling. These applications use the same precise access in different ways: recording electrical behavior, marking selected neurons, delivering material, or manipulating cellular conditions. Their value lies in linking localized interventions or measurements with individual-cell function.
Depending on the configuration, experiments can yield measurements of electrical activity, targeted delivery or manipulation, neuronal labels, or information from intracellular fluid exchange. Because the probes access individual cells or precise tissue locations, the resulting observations can connect localized cellular events with mechanisms underlying neural signaling while limiting disruption to surrounding tissue.