Retractable Insertion Shuttle
Retractable Insertion Shuttle - Related Videos
01:16
Clot Retraction and Fibrinolysis
0 Views •
2024
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
09:00
Cargo Loading onto Kinesin Powered Molecular Shuttles
0 Views •
Cited by 4 •
2010
Molecular shuttles consisting of functionalized microtubules gliding on surface-adhered kinesin motor proteins can serve as a nanoscale transport system. Here, the assembly of a typical shuttle system is described.
08:14
Central Venous Catheter Insertion: Subclavian Vein
0 Views •
2023
Source: James W Bonz, MD, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Central venous access is necessary in a multitude of clinical situations for hemodynamic monitoring, medication delivery, and blood sampling. There are three veins in the body that are accessed for central venous cannulation: the internal jugular, the subclavian, and the femoral vein. Central venous access via the subclavian vein has several advantages over other possible locations. The subclavian...
10:45
Central Venous Catheter Insertion: Femoral Vein
0 Views •
2023
Source: James W Bonz, MD, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Central venous access is necessary in a multitude of clinical situations, including vascular access, vasopressor and caustic medication delivery, central venous pressure monitoring, volume resuscitation, total parental nutrition, hemodialysis, and frequent phlebotomy. There are three veins in the body that are accessed for central venous cannulation: the internal jugular, the subclavian, and the...
08:04
Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
0 Views •
Cited by 2 •
2019
We present a protocol to build molecular shuttles, where surface-adhered kinesin motor proteins propel dye-labelled microtubules. Weak interactions of the kinesins with the surface enables their reversible attachment to it. This creates a nanoscale system which exhibits dynamic assembly and disassembly of its components while retaining its functionality.
FAQs
The shuttle supplies temporary mechanical stiffness during penetration, allowing an ultrathin or soft neural probe to reach brain tissue without relying on the probe itself to remain rigid. After placement, removing the support allows the probe to retain its intended flexibility. This separates the mechanical requirements of insertion from those of chronic neural interfacing.
Minimizing deformation helps the probe access a selected brain target while limiting disruption caused by placing a comparatively delicate device. The shuttle provides structural support only during the vulnerable insertion stage, which is particularly relevant for ultrathin or soft electrodes whose flexibility is valuable after deployment.
Withdrawal removes the rigid insertion aid after the probe has reached its target, so the support does not remain as a permanent component of the implanted system. This preserves the probe's long-term flexibility and supports the design goal of reducing mechanical mismatch with brain tissue during chronic recording or stimulation.
The probe is first supported by the shuttle, then guided into brain tissue toward the selected target. Once placement is achieved, the shuttle is withdrawn while the probe remains in the tissue. This sequence uses stiffness during penetration but leaves the neural interface in its flexible state for subsequent experiments.
Ultrathin and soft electrodes are the primary devices suited to this approach because their flexibility can make direct penetration difficult. A temporary shuttle supplies the support needed for placement, then is removed so the electrode can function without a permanent rigid backing. The approach therefore connects delicate device designs with in-tissue deployment.
In neuroscience, these shuttles support studies that require chronic neural recording or stimulation after a probe has been placed in a delicate brain region. Their use can improve access to selected targets while helping preserve the probe's flexibility and biocompatibility. The method is therefore relevant to long-term neural interface research rather than only one-time placement.