Skin Conductance Response

Skin Conductance Response (SCR) is a physiological measure of brief changes in the skin’s electrical conductance, commonly used to index sympathetic nervous system activity. When emotionally significant, attention-demanding, or stressful stimuli activate sympathetic pathways, eccrine sweat glands increase moisture at the skin surface, allowing electrical current to pass more readily and producing a measurable phasic response. In neuroscience, researchers record SCR with skin electrodes to study arousal, attention, learning, and emotional processing, including responses during conditioning and decision-making tasks. Because SCR reflects autonomic activation rather than a specific emotion, it is typically interpreted alongside behavioral, neural, and other physiological measures.

Skin Conductance Response - Related Videos

Research

JoVE Journal - Biology
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Measurement of Leaf Hydraulic Conductance and Stomatal Conductance and Their Responses to Irradiance and Dehydration Using the Evaporative Flux Method (EFM)

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Cited by 105 •

2012

We describe a relatively rapid (30 min) and realistic method for simultaneously measurement of leaf hydraulic conductance (Kleaf) and stomatal conductance (gs) for transpiring excised leaves. The method can be modified to measure the light and dehydration responses of Kleaf and gs.

Research

JoVE Journal - Immunology and Infection

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

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Cited by 10 •

2014

Tail-skin transplantation is a powerful model for studying T cell-dependent rejection and tolerance induction during allogeneic immune responses in mice. The advantages of this protocol are minor invasive surgery, and ease of monitoring with no need to sacrifice the recipient mouse.

A Technique to Assess the Immune Response against an Antigen by Inducing Skin Inflammation

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2025

This video demonstrates an in vivo technique to assess a test antigen by inducing skin inflammation in a murine model. The test antigen—a hapten in an oil/acetone solution—is topically applied to the skin of the mouse ear, and inflammation of the skin is assessed after an adequate period.

A Murine Skin Wound Infection Model to Study the Immune Response against a Bacterial Pathogen

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2025

This video demonstrates a technique to generate a murine model of skin wound infection. Upon infecting mice — engineered to express a fluorescent protein in neutrophils — with a genetically modified bioluminescent Staphylococcus aureus — a pathogenic bacteria. The bacterial burden at the infection site and the neutrophil recruitment dynamics can be studied using whole animal imaging.

Methods for Skin Wounding and Assays for Wound Responses in C. elegans

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Cited by 20 •

2014

The adult C. elegans skin is a tractable model for studies of epithelial wound responses, including wound closure, scar formation, and innate immunity.

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