Small Bore Mri
Small Bore Mri - Related Videos
06:06
Optogenetic Functional MRI
0 Views •
Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
06:58
Synthesis of an In vivo MRI-detectable Apoptosis Probe
0 Views •
Cited by 3 •
2012
Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.
12:27
Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
0 Views •
Cited by 9 •
2009
This work describes basic procedures of noninvasive small animal MRI and MRS in vivo.
09:33
MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
0 Views •
Cited by 79 •
2014
Non-invasive imaging of the brain vasculature’s ability to dilate or constrict may allow a better understanding of cerebrovascular pathophysiology in various neurological diseases. The present report describes a reproducible and patient-comfortable protocol to perform vascular reactivity imaging in humans using magnetic resonance imaging (MRI).
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
0 Views •
Cited by 5 •
2015
The goal of this study is to use magnetic resonance venography with long-circulating gadolinium-based contrast agent and direct thrombus imaging for quantitative evaluation of DVT volume in a multicenter, clinical trial setting. Inter- and intra-observer variability assessments were conducted, and reproducibility of the protocol was determined.
FAQs
The magnetic field first aligns hydrogen nuclei, while radiofrequency pulses temporarily disturb that alignment. As the nuclei return toward their prior state, they produce signals that vary according to location. Spatial gradients distinguish those locations, allowing a computer to reconstruct the signals into cross-sectional images. This coordinated process converts molecular responses into anatomical information.
A narrow bore is suited to small subjects and focused anatomical regions, where the research goal may be detailed examination rather than broad whole-body imaging. Its controlled setting also supports consistent measurements across scans. In neuroscience, this configuration helps investigators examine brain structure and tissue changes in laboratory animals under defined experimental conditions.
The raw MRI signal alone does not identify where within the subject it originated. Spatial gradients provide location-dependent information, separating signals from different parts of the imaged region. Computer reconstruction then organizes those signals into cross-sectional views, enabling researchers to relate observed tissue changes to particular anatomical locations in the brain or another localized region.
Because imaging is noninvasive, researchers can obtain measurements from the same subject at multiple points in a study. Those repeated observations help track development, injury, or responses to treatment over time rather than relying only on separate groups measured once. The approach can therefore reduce the need for repeated invasive procedures while preserving temporal information.
Small-bore imaging can support studies of brain structure, tissue changes, and disease models, particularly in laboratory animals. Researchers may use the resulting images to examine how anatomy changes during development, after injury, or during treatment. These applications connect detailed imaging with experimental questions about progression and response within controlled neuroscience studies.
Repeated scans can provide a series of measurements showing how brain structure or tissue changes evolve within an individual laboratory animal. Depending on the study design, comparisons may focus on development, injury-related changes, or treatment response. This time-linked information helps researchers assess progression and complements other experimental observations without requiring repeated invasive procedures.