Albuterol Terbutaline

Albuterol and terbutaline are short-acting β2-adrenergic receptor agonists used primarily to relieve reversible bronchoconstriction, making them important rescue medicines in pharmacology. After binding β2 receptors on airway smooth muscle, they activate Gs proteins, stimulate adenylyl cyclase, increase intracellular cyclic AMP, and promote muscle relaxation and bronchodilation. Inhaled albuterol commonly provides rapid relief during asthma or chronic obstructive pulmonary disease exacerbations, while terbutaline may be administered by inhalation, orally, or subcutaneously when additional options are needed. Comparing their routes, onset, duration, adverse effects, and selectivity helps explain clinical decision-making and risks such as tremor, tachycardia, and hypokalemia.

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