Systemic Circulation
Systemic Circulation - Related Videos
01:15
Overview of Systemic and Pulmonary Circulation
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2024
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins. The oxygenated blood is sent...
01:14
Fetal Circulation
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2024
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta. Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
01:21
Coronary Circulation
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2024
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively. Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
09:52
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
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Cited by 14 •
2011
We have developed a flow cytometer using laser induced ultrasound to detect circulating melanoma cells as an early indicator of metastatic disease.
13:19
The Use of Chemostats in Microbial Systems Biology
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Cited by 67 •
2013
Cell growth rate is a regulated process and a primary determinant of cell physiology. Continuous culturing using chemostats enables extrinsic control of cell growth rate by nutrient limitation facilitating the study of molecular networks that control cell growth and how those networks evolve to optimize cell growth.
FAQs
Systemic circulation determines drug distribution by moving medicines from the heart through progressively smaller vessels to tissue exchange sites. Once blood reaches those sites, drugs can move between the bloodstream and tissues. Consequently, the pattern of blood delivery helps determine which organs receive a medicine and how much exposure each tissue experiences.
Blood flow and tissue perfusion influence how quickly a medicine arrives at its target organ. Better delivery can support earlier exposure, whereas reduced perfusion can delay drug arrival and alter the concentration available to tissues. These circulation-dependent differences help explain why cardiovascular function can affect both the onset and strength of a therapeutic response.
Capillaries serve as the principal exchange region identified in the circulation overview. At these small-vessel sites, drugs move between blood and tissues alongside oxygen and nutrients. This exchange connects the drug concentration in circulating blood with the amount reaching organs, making capillary delivery central to tissue exposure and organ-specific pharmacological effects.
Circulating blood links several stages of a medicine's behavior in the body. It delivers the drug to tissues and organs, supports movement between blood and tissue, and carries medicines through the processes associated with metabolism and clearance. As a result, circulation helps determine how long a drug remains available, where it acts, and how its concentration changes.
A pharmacologist considers blood flow, tissue perfusion, cardiovascular function, and the resulting drug concentration in relevant organs. These factors help connect delivery through the circulation with distribution, metabolism, clearance, and therapeutic response. Examining them provides a framework for understanding why the same medicine may produce different effects when circulation or organ perfusion changes.
Therapeutic response depends not only on the medicine administered but also on how circulation delivers it to tissues. Systemic circulation supports organ function and homeostasis while influencing drug concentration, target-organ exposure, onset, and clearance. In pharmacology, this makes cardiovascular performance and tissue perfusion important context when explaining variation in treatment outcomes.