Functional Impairment
Functional Impairment - Related Videos
08:34
Thinking Too Much Impairs Decision-Making
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2023
Source: Peter Mende-Siedlecki & Jay Van Bavel—New York University When we are considering a tough choice between two or more attractive options, we often end up actively weighing the pros and cons of each alternative. By reflecting on their advantages and disadvantages, we attempt to fit a complex, subjective decision into an orderly set of criteria. However, research in psychology suggests that this sort of introspective approach might not always yield the most optimal outcomes.1 In other...
02:39
Evaluating Motor Impairment in C. elegans Models Using the Radial Locomotion Assay
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2025
This video demonstrates the use of a radial locomotion assay to evaluate motor dysfunction in C. elegans expressing either wild-type or ALS-mutant human TDP-43 protein. Worms with varying levels of wild-type or mutant TDP-43 expression are allowed to crawl, and their movement is measured by the radial distance traveled from the central point on the assay plate. The assay distinguishes between mild, moderate, and severe motor impairments based on the distance traveled by the different C. elegans...
07:52
An Automated System for Sound Localization Testing in Hearing-Impaired Listeners
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2026
This protocol introduces an automated sound localization testing system with precise loudspeaker placement and integrated response analysis, validated in normal-hearing participants and participants with single-sided deafness. It provides a reproducible method to assess spatial hearing and supports functional classification using the International Classification of Functioning, Disability and Health (ICF) framework.
08:43
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Cited by 7 •
2017
Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy controls.
16:08
Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
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Cited by 11 •
2012
We present a protocol that allows investigation of the neural mechanisms mediating the detrimental impact of emotion on cognition, using functional magnetic resonance imaging. This protocol can be used with both healthy and clinical participants.
FAQs
Clinically significant difficulty is judged partly by its practical consequences, not solely by the presence of distressing symptoms. Clinicians ask whether changes in cognition, emotion, motivation, or behavior interfere with expected responsibilities or participation. This helps separate a short-lived reaction from problems that meaningfully disrupt functioning and may warrant closer diagnostic evaluation.
Assessment is strongest when it examines several life domains rather than relying on a single setting. Relevant areas include daily activities, relationships, learning, work, and participation in society. Reviewing these domains shows whether difficulties are broad or context-specific, clarifies the person’s overall level of disruption, and prevents one isolated problem from representing the whole picture.
Developmental expectations and environmental demands shape the meaning of observed difficulties. The same behavior may have different functional significance depending on what is expected at a person’s developmental stage and what demands the surrounding environment places on them. Clinicians therefore interpret impairment in context instead of applying one fixed standard to every individual.
Functional impairment contributes to both diagnosis and severity assessment by indicating how substantially symptoms affect practical life. Two people may report similar psychological symptoms yet differ in the degree of disruption across responsibilities, relationships, or participation. Evaluating that disruption adds clinically relevant information that symptom descriptions alone may not capture.
Clinicians examine changes in cognition, emotion, motivation, and behavior, then relate those changes to performance across relevant contexts. The assessment connects psychological changes with effects on activities, relationships, learning, work, or social participation. This comparison helps identify where functioning has changed and provides a basis for clinical decisions.
Treatment planning can use impairment findings to focus care on practical difficulties as well as psychological symptoms. Reassessing functioning over time then shows whether an intervention produces meaningful improvement in everyday life. A person may experience symptom change without equivalent gains in functioning, so tracking both provides a more complete picture of treatment outcome.