Melatonin

Melatonin is a hormone that helps regulate the body’s daily sleep-wake cycle and other circadian rhythms, making it important in psychology and behavioral research. In response to signals from the brain’s suprachiasmatic nucleus, the pineal gland increases melatonin production in dim light and suppresses it during daylight, promoting nighttime sleepiness. Researchers study melatonin to understand sleep timing, biological clocks, jet lag, shift work, and how light exposure influences behavior and mental functioning. Clinical and experimental applications include assessing circadian disruption and evaluating strategies that support more regular sleep patterns.

Melatonin - Related Videos

Research

JoVE Journal - Developmental Biology

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

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Cited by 35 •

2016

This manuscript presents a unique in vitro model of immunopurified human villous cytotrophoblast cells cultured under hypoxia/reoxygenation. This model is suitable to study the protective effects of promising treatments, such as melatonin, on pregnancy complications associated with increased oxidative stress and altered placental function.

Education

JoVE Core - Biology

Types of Hormones

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2019

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells. Steroid hormones are derived from cholesterol and are lipophilic in nature. This allows them to readily traverse the lipid-rich cell membrane to bind to their intracellular receptors in the cytoplasm or nucleus. Once bound, the cytoplasmic hormone-receptor complex translocates to the nucleus.

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

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Cited by 1 •

2025

Here, we present a through-the-wall, minimally invasive method to sample blood during sleep in clinical settings.

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