Guest Editors
Antwi-Boasiako Oteng
National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH)
Antwi-B. Oteng received a BSc in Biochemistry in 2011 from the University of Ghana, an MSc in Molecular Life Science in 2014 from Wageningen University, Netherlands, and a PhD in Molecular Nutrition focusing on lipid metabolism in 2019 from Wageningen University. From June 2019 to July 2021, Dr. Oteng trained as a Postdoctoral Scientist at Columbia University, New York, investigating the potential of modulating bile acid metabolism to reverse obesity and associated metabolic complications. Dr Oteng then joined NIDDK at NIH as a Postdoc Fellow in August 2021 to investigate the role of GPCR signaling in enteroendocrine cells on systemic glucose homeostasis. Dr. Oteng is a Research Fellow with the National Human Genome Research Institute at NIH, investigating the functional roles of specific gene variants in humans that associate with cardiometabolic diseases, specifically dyslipidemia, obesity, and type-2 diabetes.
Philip Ruppert
University of Southern Denmark
Philip M. M. Ruppert is a molecular biologist with broad training in lipid and amino acid metabolism, performing wet lab and computational work. In December 2020, he completed his PhD under the supervision of Prof. Dr. Sander Kersten Wageningen University in the Netherlands. In 2021, he became an EMBO postdoctoral fellow at the University of Southern Denmark in Denmark, where he currently carries out his work under the supervision of Prof. Dr. Jan-Wilhelm Kornfeld. Philip‘s scientific interests span nutrition, metabolism, transcriptomic, and chromatin biology, focusing on the molecular underpinnings that underlie transition states such as the feeding-fasting and the room temperature-cold response.
Liu Liu
NIDDK Laboratory of Bioorganic Chemistry, Molecular Signaling Section
Liu Liu earned her BSc in Bioengineering from The Sichuan University of Science and Engineering in 2010, followed by an MSc in Microbiology from the University of Chinese Academy of Sciences in 2013. In 2019, she completed her PhD in Biomedical Sciences at Oakland University, focusing on trace elements' role in liver function. As a Postdoc Fellow at the NIDDK, NIH since November 2019, Dr. Liu investigates distinct GPCR signaling pathways in metabolic organs, including pancreatic islets and brown adipose tissue. Using designer GPCRs (DREDDs), her work delves into glucagon secretion from pancreatic α cells via Gq and Gs pathways and the impact of Gi signaling on brown adipose tissue thermogenesis.
Collection Overview
Normal systemic glucose homeostasis is fundamental for preventing obesity-associated metabolic diseases like type-2 diabetes. Type-2 diabetes ranks among the world's top causes of mortality and morbidity today. It is characterized by hyperglycemia stemming from insulin resistance or decreased insulin secretion, or both, resulting in unwarranted complications like retinopathy, neuropathy, and nephropathy. Efficient methods for determining local and systemic glucose homeostasis are crucial for designing therapeutic strategies against type 2 diabetes and other metabolic disorders.
Several methodologies are employed to assess glucose homeostasis. This Methods Collection focuses on experimental designs used to study glucose homeostasis in clinical studies, pre-clinical animal models, and in vitro experiments by:
- promoting established techniques currently employed to address experimental questions on glucose metabolism.
- highlighting novel ideas aimed at enhancing these established techniques.
- advancing novel methods for investigating glucose metabolism across various experimental models.
The overarching objective is to present concise and comprehensible details of different experimental techniques that can be utilized to study glucose homeostasis, to enhance reproducibility and reduce variations in experimental outcomes across different research groups or labs.
