Uppercase Notation

Uppercase notation in statistics is a convention for representing random variables, distinguishing uncertain quantities from the observed values they produce. An uppercase symbol such as X denotes a variable governed by a probability distribution, while its lowercase counterpart x denotes one realized outcome; expressions such as P(X = x) and E[X] describe probabilities and expected values using this distinction. Consistent notation clarifies the difference between a statistical model and collected data, supports precise statements about distributions and estimators, and helps researchers interpret sampling, hypothesis testing, regression, and other inferential procedures.

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Education

JoVE Core - Math Fundamentals

Summation Notation

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2025

Sigma notation, also known as summation notation, provides a concise method for representing the sum of a sequence of terms that follow a regular pattern. It utilizes the uppercase Greek letter sigma (∑), A typical expression is:In this form, k the index of summation is 1, the starting value, and n the ending value. The term ak​ represents the general term of the sequence.For example, the increasing sequence 5, 7, 9, ..., 23 over 10 terms can be expressed as:This simplifies the representation...

¹H NMR: Pople Notation

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2024

The Pople nomenclature system classifies spin systems based on the difference between their chemical shifts. Coupled spins are denoted by capital letters with subscripts indicating the number of equivalent nuclei. When the coupled nuclei have well-separated chemical shifts, they are assigned letters that are far apart in the alphabet, such as A and X. When the difference in chemical shifts is small, coupled nuclei are named using adjacent letters of the alphabet (AB, MN, or XY). A proton...

Scalar Notation

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2023

Scalar notation is a useful method for simplifying calculations involving vectors. When vectors are added or subtracted, their components can be added or subtracted separately using scalar notation. For instance, force, a vector quantity, can be broken down into its x and y components, called rectangular components, and then the magnitude and direction of these components can be determined using trigonometric functions. Consider a man pulling a rope from a hook in the northeast direction. The...

Cartesian Vector Notation

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2023

Cartesian vector notation is a valuable tool in mechanical engineering for representing vectors in three-dimensional space, performing vector operations such as determining the gradient, divergence, and curl, and expressing physical quantities such as the displacement, velocity, acceleration, and force. By using Cartesian vector notation, engineers can more easily analyze and solve problems in various areas of mechanical engineering, including dynamics, kinematics, and fluid mechanics. This...

Research

JoVE Journal - Developmental Biology

Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System

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Cited by 5 •

2015

Genome editing tools such as the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated) system have greatly improved gene targeting efficiency in human induced pluripotent stem cells (hiPSCs). This manuscript describes a protocol for generating lineage specific hiPSC reporter using CRISPR/Cas system assisted homologous recombination.

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